Lithium chloride: An active and simple catalyst for cyanosilylation of aldehydes and ketones

被引：135

作者：

Kurono, N ^{[1
]}

Yamaguchi, M ^{[1
]}

Suzuki, K ^{[1
]}

Ohkuma, T ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Engn, Div Chem Proc Engn, Sapporo, Hokkaido 0608628, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 16期

关键词：

D O I：

10.1021/jo050791t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

LiCl acts as a highly effective catalyst for cyanosilylation of various aldehydes and ketones to the corresponding silylated cyanohydrins. The reaction proceeds smoothly with a substrate/catalyst molar ratio of 100-100 000 at 20-25 degrees C under solvent-free conditions. alpha,beta-Unsaturated aldehydes are completely converted to the 1,2-adducts. The cyanation products can be isolated by direct distillation of the reaction mixture.

引用

页码：6530 / 6532

页数：3

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