Does the spread of hepatitis B virus genotype A increase the risk of intrafamilial transmission in Japan?

被引：6

作者：

Komatsu, Haruki ^{[1
]}

Sugawara, Hidenori ^{[1
]}

Inui, Ayano ^{[1
]}

Nagamine, Kenjiro ^{[2
]}

Hiejima, Eitaro ^{[1
]}

Sogo, Tsuyoshi ^{[1
]}

Fujisawa, Tomoo ^{[1
]}

机构：

[1] Eastern Yokohama Hosp, Dept Pediat, Tsurumi ku, Kanagawa, Japan

[2] Fujiyoshida Municipal Med Ctr, Dept Pediat, Fujiyoshida, Yamanashi, Japan

来源：

JOURNAL OF INFECTION AND CHEMOTHERAPY | 2011年 / 17卷 / 02期

关键词：

HBV; Genotype A; Child; Horizontal transmission; Universal vaccination; ACUTE INFECTION; HBV INFECTION; DNA;

D O I：

10.1007/s10156-010-0107-z

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Recently, the prevalence of genotype A in patients with acute hepatitis B virus (HBV) infection has markedly increased in Japan. We encountered a 1-year-old infant who was infected with HBV genotype A and became an HBV carrier. His grandfather was identified as an HBV carrier; however, the grandfather was not aware of chronic HBV infection. This was a case of intrafamilial transmission. In addition, the child's father developed acute hepatitis B within 1 month of the infant's diagnosis. Molecular analysis revealed that the HBV isolates from the grandfather, the infant, and the father had identical sequences that belonged to genotypes A2/Ae. Compared with other HBV genotypes, genotype A has a significant association with chronic outcome. Therefore, prolonging hepatitis can increase the risk of transmitting the virus without realizing. The at-risk strategy of hepatitis B vaccination, which has been adopted in Japan, cannot prevent such intrafamilial transmission. Universal vaccination in childhood is only one way to prevent young children from unexpected HBV infection.

引用

页码：272 / 277

页数：6

共 50 条

[41] Analysis of Hepatitis B Virus Genotype Changes in Patients with Chronic Hepatitis B Infection on Tenofovir Therapy [J].

Chauhan, Ranjit ;

Singh, Avishek K. ;

Rooge, Sheetalnath ;

Varshney, Aditi ;

Kumar, Manoj ;

Sarin, Shiv K. .

JOURNAL OF MEDICAL VIROLOGY, 2016, 88 (08) :1364-1375

[42] HORIZONTAL TRANSMISSION OF HEPATITIS-B VIRUS IN CHILDREN [J].

HSU, SC ;

CHANG, MH ;

NI, YH ;

HSU, HY ;

LEE, CY .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 1993, 16 (01) :66-69

[43] Risk factors and mechanism of transplacental transmission of hepatitis B virus: A case-control study [J].

Xu, DZ ;

Yan, YP ;

Choi, BCK ;

Xu, JQ ;

Men, K ;

Zhang, JX ;

Liu, ZH ;

Wang, FS .

JOURNAL OF MEDICAL VIROLOGY, 2002, 67 (01) :20-26

[44] Study on family aggregation and risk factors of hepatitis B virus transmission in Chaoyang District,Beijing [J].

庞星火 .

China Medical Abstracts(Internal Medicine), 2012, 29 (04) :223-224

[45] Establishment of reference sequences of hepatitis B virus genotype C subgenotypes [J].

Zhu, H. L. ;

Wang, C. T. ;

Xia, J. B. ;

Li, X. ;

Zhang, Z. H. .

GENETICS AND MOLECULAR RESEARCH, 2015, 14 (04) :16521-16534

[46] Acute hepatitis B virus infection in Turkey: epidemiology and genotype distribution [J].

Leblebicioglu, H ;

Eroglu, C ;

Aribas, E ;

Sirmatel, F ;

Ayaz, C ;

Ozsoy, MF ;

Cavuslu, S ;

Turkyilmaz, R ;

Tutuncu, E ;

Sunbul, M ;

Esen, S ;

Turan, D ;

Akbulut, A ;

Cihangiroglu, M ;

Aygen, B ;

Yildiz, O ;

Usluer, G ;

Kartal, ED ;

Irmak, H ;

Evirgen, O ;

Tulek, N ;

Yetkin, MA ;

Dokmetas, I ;

Bakir, M ;

Ozgenc, O ;

Parlak, M ;

Parlak, E ;

Koksal, I ;

Caylan, R ;

Sencan, I ;

Yamazhan, T ;

Ulusoy, S ;

Akcam, Z ;

Yayli, G ;

Ersoz, G ;

Kaya, A ;

Saltoglu, N ;

Tasova, Y ;

Ersoy, Y ;

Kilic, D ;

Kaygusuz, S .

CLINICAL MICROBIOLOGY AND INFECTION, 2004, 10 (06) :537-541

[47] Does hepatitis C virus affect the reactivation of hepatitis B virus following renal transplantation? [J].

Yen, TH ;

Huang, CC ;

Lin, HH ;

Huang, JY ;

Tian, YC ;

Yang, CW ;

Wu, MS ;

Fang, JT ;

Yu, CC ;

Chiang, YJ ;

Chu, SH .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2006, 21 (04) :1046-1052

[48] Molecular Evolution and Phylodynamics of Acute Hepatitis B Virus in Japan [J].

Lin, Serena Y. C. ;

Toyoda, Hidenori ;

Kumada, Takashi ;

Liu, Hsin-Fu .

PLOS ONE, 2016, 11 (06)

[49] Hepatitis B virus detected in paper currencies in a densely populated city of India: A plausible source of horizontal transmission? [J].

Das, Palashpriya ;

Supekar, Ruchi ;

Chatterjee, Ritika ;

Roy, Subrata ;

Ghosh, Anisa ;

Biswas, Subhajit .

WORLD JOURNAL OF HEPATOLOGY, 2020, 12 (10) :775-791

[50] Fulminant hepatitis B and acute hepatitis B due to intrafamilial transmission of HBV after chemotherapy for non-Hodgkin’s lymphoma in an HBV carrier [J].

Tomoki Aomatsu ;

Haruki Komatsu ;

Atsushi Yoden ;

Akiko Hosomi ;

Hiroshi Miyazaki ;

Tsuyoshi Sogo ;

Ayano Inui ;

Tomoo Fujisawa ;

Hiroshi Tamai .

European Journal of Pediatrics, 2010, 169 :167-171

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