Does the spread of hepatitis B virus genotype A increase the risk of intrafamilial transmission in Japan?

被引：6

作者：

Komatsu, Haruki ^{[1
]}

Sugawara, Hidenori ^{[1
]}

Inui, Ayano ^{[1
]}

Nagamine, Kenjiro ^{[2
]}

Hiejima, Eitaro ^{[1
]}

Sogo, Tsuyoshi ^{[1
]}

Fujisawa, Tomoo ^{[1
]}

机构：

[1] Eastern Yokohama Hosp, Dept Pediat, Tsurumi ku, Kanagawa, Japan

[2] Fujiyoshida Municipal Med Ctr, Dept Pediat, Fujiyoshida, Yamanashi, Japan

来源：

JOURNAL OF INFECTION AND CHEMOTHERAPY | 2011年 / 17卷 / 02期

关键词：

HBV; Genotype A; Child; Horizontal transmission; Universal vaccination; ACUTE INFECTION; HBV INFECTION; DNA;

D O I：

10.1007/s10156-010-0107-z

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Recently, the prevalence of genotype A in patients with acute hepatitis B virus (HBV) infection has markedly increased in Japan. We encountered a 1-year-old infant who was infected with HBV genotype A and became an HBV carrier. His grandfather was identified as an HBV carrier; however, the grandfather was not aware of chronic HBV infection. This was a case of intrafamilial transmission. In addition, the child's father developed acute hepatitis B within 1 month of the infant's diagnosis. Molecular analysis revealed that the HBV isolates from the grandfather, the infant, and the father had identical sequences that belonged to genotypes A2/Ae. Compared with other HBV genotypes, genotype A has a significant association with chronic outcome. Therefore, prolonging hepatitis can increase the risk of transmitting the virus without realizing. The at-risk strategy of hepatitis B vaccination, which has been adopted in Japan, cannot prevent such intrafamilial transmission. Universal vaccination in childhood is only one way to prevent young children from unexpected HBV infection.

引用

页码：272 / 277

页数：6

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