Hedgehog signalling and the specification of muscle cell identity in the Zebrafish embryo

被引：45

作者：

Ingham, PW ^{[1
]}

Kim, HR ^{[1
]}

机构：

[1] Univ Sheffield, Ctr Dev & Biomed Genet, Sheffield S10 2TN, S Yorkshire, England

来源：

EXPERIMENTAL CELL RESEARCH | 2005年 / 306卷 / 02期

关键词：

hedgehog signalling; Zebrafish; muscle cell; Blimp1; slow twitch fibre;

D O I：

10.1016/j.yexcr.2005.03.019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Signalling by members of the Hedgehog family of secreted proteins plays a central role in the development of many animal species. In the zebrafish embryo, the specification of myoblast fates is controlled by Hedgehog signals emanating from axial midline structures. Distinct muscle cell identities are induced by varying levels of signalling activity. The SET domain transcription factor, Blimp I, is a key target of Hedgehog signalling in this process. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：336 / 342

页数：7

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