Palladium-Catalyzed Borylation of Aryl Mesylates and Tosylates and Their Applications in One-Pot Sequential Suzuki-Miyaura Biaryl Synthesis

被引：71

作者：

Chow, Wing Kin ^{[1
,2
]}

So, Chau Ming ^{[1
,2
]}

Lau, Chak Po ^{[1
,2
]}

Kwong, Fuk Yee ^{[1
,2
]}

机构：

[1] Hong Kong Polytech Univ, State Key Lab Chirosci, Hung Hom Kowloon, Hong Kong, Peoples R China

[2] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hung Hom Kowloon, Hong Kong, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2011年 / 17卷 / 25期

关键词：

biaryls; borylation; cross-coupling; palladium; phosphine; tosylates; CROSS-COUPLING REACTION; ROOM-TEMPERATURE; HALIDES; CHLORIDES; SYSTEM; ROUTE; NEOPENTYLGLYCOLBORYLATION; PINACOLBORANE; DIALKOXYBORANE; BROMIDES;

D O I：

10.1002/chem.201100361

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Top of the one-pots! The first palladium-catalyzed borylation of aryl tosylates and mesylates is described. The reaction conditions are mild and provide excellent functional-group compatibility (e.g., R=CN, CHO, COOMe, C(O)R, NH2, or NH-indole; see scheme). Pd/MeO-CM-phos allows one-pot sequential reactions in the preparation of unsymmetrical biaryls. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6913 / 6917

页数：5

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