Is Gut Involvement a Cause or Effect of COVID-19?

被引：0

作者：

Zulkifli, Khairil Khuzaini ^{[1
]}

Oon, Tan Phei ^{[2
]}

Mustaffa, Nazri ^{[2
]}

Young, Chuah Yoen ^{[3
]}

Muthukaruppan, Raman ^{[4
,5
]}

Feei, Ma Zheng ^{[2
]}

Yeh, Lee Yeong ^{[2
]}

机构：

[1] Univ Teknol MARA, Fac Med, Sungai Buloh, Selangor, Malaysia

[2] Univ Sains Malaysia, Sch Med Sci, Kubang Kerian, Kelantan, Malaysia

[3] Ping Tung Christian Hosp, Dept Internal Med, Div Gastroenterol & Hepatol, Pingtung, Taiwan

[4] Hosp Queen Elizabeth, Dept Med, Kota Kinabalu, Sabah, Malaysia

[5] Hosp Queen Elizabeth, Gastroenterol Unit, Kota Kinabalu, Sabah, Malaysia

来源：

MALAYSIAN JOURNAL OF MEDICAL SCIENCES | 2021年 / 28卷 / 06期

基金：

英国科研创新办公室;

关键词：

COVID-19; SARS-CoV-2; ACE2; gastrointestinal tract; liver; CORONAVIRUS; SARS-COV-2; DISEASE;

D O I：

10.21315/mjms2021.28.6.14

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Digestive disorder symptoms in COVID-19 may be similar in form to post-infectious functional gastrointestinal disorder (PI-FGID). To cause clinical effects, SARS-CoV-2 must reach the bowels and gastric hypochlorhydria may facilitate such transit. Asian elderly are predisposed to greater infection rate and severity of COVID-19, and the high prevalence of gastric atrophy and intake of proton-pump inhibitor in this aged group might explain the risk. Persistence shedding of SARS-CoV-2 in stools indicates that faecal transmission should not be disregarded. Gut involvement in COVID-19 is mediated by angiotensin-converting enzyme 2 (ACE2) receptor, which serves as the entry point for SARS-CoV-2 in the small bowel. ACE2 dysregulation has an impact on the homeostasis of gut microbiota and altered inflammatory response. Liver injury is variable in COVID-19 and is likely a result of by-stander effects rather than actual viropathic process. Further research is needed to understand if gut involvement is a cause or effect of SARS-CoV-2.

引用

页码：186 / 193

页数：8

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