Gut microbiome development and childhood undernutrition

被引:21
作者
Barratt, Michael J. [1 ,2 ]
Ahmed, Tahmeed [3 ]
Gordon, Jeffrey, I [1 ,2 ]
机构
[1] Washington Univ, Edison Family Ctr Genome Sci & Syst Biol, St Louis, MO 63110 USA
[2] Washington Univ, Ctr Gut Microbiome Res, St Louis, MO 63110 USA
[3] Bangladesh Icddr B, Int Ctr Diarrhoea Dis Res, Dhaka 1212, Bangladesh
基金
美国国家卫生研究院; 比尔及梅琳达.盖茨基金会;
关键词
NUTRITIONAL-STATUS; INFANT; BIOPSY; NEEDS; FOOD;
D O I
10.1016/j.chom.2022.04.002
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Forty-five percent of deaths among children under 5 years of age are associated with undernutrition. Globally, almost 200 million children exhibit the two major forms of undernutrition???wasting (low weight-forheight) or stunting (low height-for-age), with many affected by both. Undernutrition is not due to food insecurity alone. Growing evidence indicates that perturbed postnatal gut microbiome development contributes to its pathogenesis. This perspective focuses on defining and repairing these defects in gut microbiome development. We describe an approach that involves the analysis of well-phenotyped human cohorts, followed by preclinical studies using gnotobiotic animals colonized with microbiota from these cohorts. Additionally, these models can be used to identify therapeutic targets and candidates that can then be tested clinically. Furthermore, introducing pretreatment microbiota from trial participants into gnotobiotic animals and re-enacting trial conditions allow mechanisms to be dissected. We highlight these recent advances as well as gaps in existing knowledge that present opportunities for future research.
引用
收藏
页码:617 / 626
页数:10
相关论文
共 57 条
  • [1] [Anonymous], 2009, WHO CHILD GROWTH STA
  • [2] Dietary diversity is associated with child nutritional status: Evidence from 11 Demographic and Health Surveys
    Arimond, M
    Ruel, MT
    [J]. JOURNAL OF NUTRITION, 2004, 134 (10) : 2579 - 2585
  • [3] Studying Vertical Microbiome Transmission from Mothers to Infants by Strain-Level Metagenomic Profiling
    Asnicar, Francesco
    Manara, Serena
    Zolfo, Moreno
    Duy Tin Truong
    Scholz, Matthias
    Armanini, Federica
    Ferretti, Pamela
    Gorfer, Valentina
    Pedrotti, Anna
    Tett, Adrian
    Segata, Nicola
    [J]. MSYSTEMS, 2017, 2 (01)
  • [4] Bäckhed F, 2015, CELL HOST MICROBE, V17, P690, DOI [10.1016/j.chom.2015.04.004, 10.1016/j.chom.2015.05.012]
  • [5] Human Milk Composition Nutrients and Bioactive Factors
    Ballard, Olivia
    Morrow, Ardythe L.
    [J]. PEDIATRIC CLINICS OF NORTH AMERICA, 2013, 60 (01) : 49 - +
  • [6] Bifidobacterium infantis treatment promotes weight gain in Bangladeshi infants with severe acute malnutrition
    Barratt, Michael J.
    Nuzhat, Sharika
    Ahsan, Kazi
    Frese, Steven A.
    Arzamasov, Aleksandr A.
    Sarker, Shafiqul Alam
    Islam, M. Munirul
    Palit, Parag
    Islam, Md Ridwan
    Hibberd, Matthew C.
    Nakshatri, Swetha
    Cowardin, Carrie A.
    Guruge, Janaki L.
    Byrne, Alexandra E.
    Venkatesh, Siddarth
    Sundaresan, Vinaik
    Henrick, Bethany
    Duar, Rebbeca M.
    Mitchell, Ryan D.
    Casaburi, Giorgio
    Prambs, Johann
    Flannery, Robin
    Mahfuz, Mustafa
    Rodionov, Dmitry A.
    Osterman, Andrei L.
    Kyle, David
    Ahmed, Tahmeed
    Gordon, Jeffrey, I
    [J]. SCIENCE TRANSLATIONAL MEDICINE, 2022, 14 (640)
  • [7] Maternal and child undernutrition and overweight in low-income and middle-income countries
    Black, Robert E.
    Victora, Cesar G.
    Walker, Susan P.
    Bhutta, Zulfiqar A.
    Christian, Parul
    de Onis, Mercedes
    Ezzati, Majid
    Grantham-McGregor, Sally
    Katz, Joanne
    Martorell, Reynaldo
    Uauy, Ricardo
    [J]. LANCET, 2013, 382 (9890) : 427 - 451
  • [8] MICROBIOTA Childhood undernutrition, the gut microbiota, and microbiota-directed therapeutics
    Blanton, Laura V.
    Barratt, Michael J.
    Charbonneau, Mark R.
    Ahmed, Tahmeed
    Gordon, Jeffrey I.
    [J]. SCIENCE, 2016, 352 (6293)
  • [9] Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children
    Blanton, Laura V.
    Charbonneau, Mark R.
    Salih, Tarek
    Barratt, Michael J.
    Venkatesh, Siddarth
    Ilkaveya, Olga
    Subramanian, Sathish
    Manary, Mark J.
    Trehan, Indi
    Jorgensen, Josh M.
    Fan, Yue-mei
    Henrissat, Bernard
    Leyn, Semen A.
    Rodionov, Dmitry A.
    Osterman, Andrei L.
    Maleta, KennethM.
    Newgard, Christopher B.
    Ashorn, Per
    Dewey, Kathryn G.
    Gordon, Jeffrey I.
    [J]. SCIENCE, 2016, 351 (6275)
  • [10] Human milk oligosaccharides: Every baby needs a sugar mama
    Bode, Lars
    [J]. GLYCOBIOLOGY, 2012, 22 (09) : 1147 - 1162