Recent Advances in Type-2-Cell-Mediated Immunity: Insights from Helminth Infection

被引：158
作者：
Harris, Nicola L. [1 ]
Loke, P'ng [2 ]
机构：
[1] Ecole Polytech Fed Lausanne, Global Hlth Inst, CH-1015 Lausanne, Switzerland
[2] NYU, Sch Med, Dept Microbiol, New York, NY 10016 USA
来源：
IMMUNITY | 2017年 / 47卷 / 06期
基金：
欧洲研究理事会; 美国国家卫生研究院;
关键词：
INNATE LYMPHOID-CELLS; ALTERNATIVELY ACTIVATED MACROPHAGES; TISSUE-RESIDENT MACROPHAGES; TYPE-2; IMMUNITY; MAST-CELLS; TRICHINELLA-SPIRALIS; PROTECTIVE IMMUNITY; LUNG INFLAMMATION; IL-13; PRODUCTION; DENDRITIC CELLS;
D O I：
10.1016/j.immuni.2017.11.015
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Type-2-cell-mediated immune responses play a critical role in mediating both host-resistance and disease-tolerance mechanisms during helminth infections. Recently, type 2 cell responses have emerged as major regulators of tissue repair and metabolic homeostasis even under steady-state conditions. In this review, we consider how studies of helminth infection have contributed toward our expanding cellular and molecular understanding of type-2-cell-mediated immunity, as well as new areas such as the microbiome. By studying how these successful parasites form chronic infections without overt pathology, we are gaining additional insights into allergic and inflammatory diseases, as well as normal physiology.
引用
收藏
页码：1024 / 1036
页数：13
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