Recent Advances in Type-2-Cell-Mediated Immunity: Insights from Helminth Infection

被引：158

作者：

Harris, Nicola L. ^{[1
]}

Loke, P'ng ^{[2
]}

机构：

[1] Ecole Polytech Fed Lausanne, Global Hlth Inst, CH-1015 Lausanne, Switzerland

[2] NYU, Sch Med, Dept Microbiol, New York, NY 10016 USA

来源：

IMMUNITY | 2017年 / 47卷 / 06期

基金：

欧洲研究理事会; 美国国家卫生研究院;

关键词：

INNATE LYMPHOID-CELLS; ALTERNATIVELY ACTIVATED MACROPHAGES; TISSUE-RESIDENT MACROPHAGES; TYPE-2; IMMUNITY; MAST-CELLS; TRICHINELLA-SPIRALIS; PROTECTIVE IMMUNITY; LUNG INFLAMMATION; IL-13; PRODUCTION; DENDRITIC CELLS;

D O I：

10.1016/j.immuni.2017.11.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Type-2-cell-mediated immune responses play a critical role in mediating both host-resistance and disease-tolerance mechanisms during helminth infections. Recently, type 2 cell responses have emerged as major regulators of tissue repair and metabolic homeostasis even under steady-state conditions. In this review, we consider how studies of helminth infection have contributed toward our expanding cellular and molecular understanding of type-2-cell-mediated immunity, as well as new areas such as the microbiome. By studying how these successful parasites form chronic infections without overt pathology, we are gaining additional insights into allergic and inflammatory diseases, as well as normal physiology.

引用

页码：1024 / 1036

页数：13

共 153 条

[1] Memory TH2 cells induce alternatively activated macrophages to mediate protection against nematode parasites [J].

Anthony, Robert M. ;

Urban, Joseph F., Jr. ;

Alem, Farhang ;

Hamed, Hossein A. ;

Rozo, Cristina T. ;

Boucher, Jean-Luc ;

Van Rooijen, Nico ;

Gause, William C. .

NATURE MEDICINE, 2006, 12 (08) :955-960

[2] RAPID EXPULSION OF TRICHINELLA-SPIRALIS IN SUCKLING RATS [J].

APPLETON, JA ;

MCGREGOR, DD .

SCIENCE, 1984, 226 (4670) :70-72

[3] Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota [J].

Atarashi, Koji ;

Tanoue, Takeshi ;

Oshima, Kenshiro ;

Suda, Wataru ;

Nagano, Yuji ;

Nishikawa, Hiroyoshi ;

Fukuda, Shinji ;

Saito, Takuro ;

Narushima, Seiko ;

Hase, Koji ;

Kim, Sangwan ;

Fritz, Joelle V. ;

Wilmes, Paul ;

Ueha, Satoshi ;

Matsushima, Kouji ;

Ohno, Hiroshi ;

Olle, Bernat ;

Sakaguchi, Shimon ;

Taniguchi, Tadatsugu ;

Morita, Hidetoshi ;

Hattori, Masahira ;

Honda, Kenya .

NATURE, 2013, 500 (7461) :232-+

[4] Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species [J].

Atarashi, Koji ;

Tanoue, Takeshi ;

Shima, Tatsuichiro ;

Imaoka, Akemi ;

Kuwahara, Tomomi ;

Momose, Yoshika ;

Cheng, Genhong ;

Yamasaki, Sho ;

Saito, Takashi ;

Ohba, Yusuke ;

Taniguchi, Tadatsugu ;

Takeda, Kiyoshi ;

Hori, Shohei ;

Ivanov, Ivaylo I. ;

Umesaki, Yoshinori ;

Itoh, Kikuji ;

Honda, Kenya .

SCIENCE, 2011, 331 (6015) :337-341

[5] Macrophage activation governs schistosomiasis-induced inflammation and fibrosis [J].

Barron, Luke ;

Wynn, Thomas A. .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2011, 41 (09) :2509-2514

[6] Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm [J].

Bethony, J ;

Brooker, S ;

Albonico, M ;

Geiger, SM ;

Loukas, A ;

Diemert, D ;

Hotez, PJ .

LANCET, 2006, 367 (9521) :1521-1532

[7] Antibodies Trap Tissue Migrating Helminth Larvae and Prevent Tissue Damage by Driving IL-4Rα-Independent Alternative Differentiation of Macrophages [J].

Bieren, Julia Esser-von ;

Mosconi, Ilaria ;

Guiet, Romain ;

Piersgilli, Alessandra ;

Volpe, Beatrice ;

Chen, Fei ;

Gause, William C. ;

Seitz, Arne ;

Verbeek, J. Sjef ;

Harris, Nicola L. .

PLOS PATHOGENS, 2013, 9 (11)

[8] Strongyloides ratti Infection Induces Expansion of Foxp3+ Regulatory T Cells That Interfere with Immune Response and Parasite Clearance in BALB/c Mice [J].

Blankenhaus, Birte ;

Klemm, Ulrike ;

Eschbach, Marie-Luise ;

Sparwasser, Tim ;

Huehn, Jochen ;

Kuehl, Anja A. ;

Loddenkemper, Christoph ;

Jacobs, Thomas ;

Breloer, Minka .

JOURNAL OF IMMUNOLOGY, 2011, 186 (07) :4295-4305

[9] Liver-Resident Macrophage Necroptosis Orchestrates Type 1 Microbicidal Inflammation and Type-2-Mediated Tissue Repair during Bacterial Infection [J].

Bleriot, Camille ;

Dupuis, Theo ;

Jouvion, Gregory ;

Eberl, Gerard ;

Disson, Olivier ;

Lecuit, Marc .

IMMUNITY, 2015, 42 (01) :145-158

[10] Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells [J].

Bosurgi, Lidia ;

Cao, Y. Grace ;

Cabeza-Cabrerizo, Mar ;

Tucci, Andrea ;

Hughes, Lindsey D. ;

Kong, Yong ;

Weinstein, Jason S. ;

Licona-Limon, Paula ;

Schmid, Edward T. ;

Pelorosso, Facundo ;

Gagliani, Nicola ;

Craft, Joseph E. ;

Flavell, Richard A. ;

Ghosh, Sourav ;

Rothlin, Carla V. .

SCIENCE, 2017, 356 (6342) :1072-+

← 1 2 3 4 5 6 7 8 9 10 →