PYP-1, inorganic pyrophosphatase, is required for larval development and intestinal function in C-elegans

被引：42

作者：

Ko, Kyung Min ^{[2
]}

Lee, Wonhae ^{[3
]}

Yu, Jae-Ran ^{[4
]}

Ahnn, Joohong ^{[1
]}

机构：

[1] Hanyang Univ, Coll Nat Sci, Dept Life Sci, Seoul 133791, South Korea

[2] GIST, Dept Life Sci, Cell Dynam Res Ctr, Kwangju 500712, South Korea

[3] Natl Inst Sci Invest, DNA Anal Div, Seoul 158097, South Korea

[4] Konkuk Univ, Sch Med, Dept Environm & Trop Med, Seoul 143701, South Korea

来源：

FEBS LETTERS | 2007年 / 581卷 / 28期

关键词：

inorganic pyrophosphatase; PYP-1; deletion mutant; larval arrest; C; elegans;

D O I：

10.1016/j.febslet.2007.10.047

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inorganic pyrophosphatase ( PPase) catalyzes the hydrolysis of inorganic pyrophosphate (PPi) into phosphate ( Pi), which provides a thermodynamic driving force for important biosynthetic reactions. The nematode Caenorhabditis elegans gene C47E12.4 encodes a PPase (PYP-1) which shows 54% amino acid identity with human PPase. PYP-1 exhibits specific enzyme activity and is mainly expressed in the intestinal and nervous system. A null mutant of pyp-1 reveals a developmental arrest at early larval stages and exhibits gross defects in intestinal morphology and function. The larval arrest phenotype was successfully rescued by reintroduction of the pyp-1 gene, suggesting that PYP-1 is required for larval development and intestinal function in C. elegans. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：5445 / 5453

页数：9

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