Bioconversion of compactin into pravastatin by Streptomyces sp.

被引：65

作者：

Park, JW

Lee, JK

Kwon, TJ

Yi, DH

Kim, YJ

Moon, SH

Suh, HH

Kang, SM

Park, YI

机构：

[1] Catholic Univ Korea, Div Biotechnol, Puchon 420743, Gyonggi Do, South Korea

[2] Youngjin Pharmaceut Co Ltd, Biotechnol Lab, Pyungtaek Si 451860, South Korea

[3] Konkuk Univ, Dept Microbial Engn, Seoul 133701, South Korea

[4] Chinju Natl Univ, Dept Environm Engn, Chinju 660758, South Korea

[5] Catholic Univ Korea, Collaborat Inst Sci & Technol, Puchon 420743, Gyonggi Do, South Korea

来源：

BIOTECHNOLOGY LETTERS | 2003年 / 25卷 / 21期

关键词：

bioconversion; compactin; cytochrome P-450; pavastatin; Streptomyces sp;

D O I：

10.1023/A:1026281914301

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Streptomyces sp. Y-110, isolated from soil, modified compactin to pravastatin, a therapeutic agent for hypercholesterolemia. In a batch culture, the highest production of pravastatin was 340 mg l(-1) from 750 mg compactin l(-1) in 24 h. By intermittent feeding of compactin into the culture medium, both the compactin concentration and its conversion increased to 2000 mg l(-1) and 1000 mg pravastatin l(-1), respectively, with the conversion rate of 10 mg l(-1) h(-1). Continuous feeding of compactin increased production of pravastatin to 15 mg l(-1) h(-1).

引用

页码：1827 / 1831

页数：5

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