The Role of Immunotherapy in the Treatment of Advanced Cervical Cancer: Current Status and Future Perspectives

被引：19
作者：
Walsh, Robert J. [1 ]
Tan, David S. P. [1 ,2 ]
机构：
[1] Natl Univ Canc Inst, Singapore 119074, Singapore
[2] Natl Univ Singapore, Canc Sci Inst, Singapore 117599, Singapore
来源：
JOURNAL OF CLINICAL MEDICINE | 2021年 / 10卷 / 19期
基金：
英国医学研究理事会;
关键词：
cervical cancer; immunotherapy; immune checkpoint inhibitor; SQUAMOUS-CELL CARCINOMA; NIVOLUMAB PLUS IPILIMUMAB; PHASE-II; T-CELLS; MICROSATELLITE INSTABILITY; INTRAEPITHELIAL NEOPLASIA; ACQUIRED-RESISTANCE; EXPRESSION; CHEMOTHERAPY; PD-L1;
D O I：
10.3390/jcm10194523
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cervical cancer remains one of the most common cancers in women around the world however therapeutic options in the advanced and recurrent setting are limited. Immune checkpoint inhibitors (ICI) have been considered an attractive option given the viral etiology of cervical cancer although the majority of patients do not benefit from their use. This review summarises current knowledge and use of immune checkpoint blockade in cervical cancer as well as discussing the challenges faced in their clinical application, namely, the role of biomarker-driven ICI use, potential mechanisms of resistance, strategies to overcome such resistance and additional immunotherapy options beyond ICI.
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页数：14
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