Glancing behind virus load variation in HIV-1 infection

被引：47

作者：

Bonhoeffer, S ^{[1
]}

Funk, GA

Günthard, HF

Fischer, M

Müller, V

机构：

[1] ETH, ETH Zentrum NW, CH-8092 Zurich, Switzerland

[2] Univ Zurich Hosp, Div Infect Dis, CH-8091 Zurich, Switzerland

来源：

TRENDS IN MICROBIOLOGY | 2003年 / 11卷 / 11期

基金：

匈牙利科学研究基金会;

关键词：

D O I：

10.1016/j.tim.2003.09.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although the steady-state virus load during HIV-1 infection is remarkably stable within a patient, it displays variation over several orders of magnitude between patients. Despite intensive research, the host and virus factors that are responsible for the observed variation remain poorly understood. Comparison of model predictions with clinical data suggests that most of the variation in steady-state virus load between patients reflects variation of the net rate at which activated CD4 cells are produced.

引用

收藏

页码：499 / 504

页数：6

相关论文

共 39 条

[31] Decay characteristics of HIV-1-infected compartments during combination therapy [J].

Perelson, AS ;

Essunger, P ;

Cao, YZ ;

Vesanen, M ;

Hurley, A ;

Saksela, K ;

Markowitz, M ;

Ho, DD .

NATURE, 1997, 387 (6629) :188-191

[32] Variation in plasma RNA levels, CD4 cell counts, and p24 antigen levels in clinically stable men with human immunodeficiency virus infection [J].

Raboud, JM ;

Montaner, JSG ;

Conway, B ;

Haley, L ;

Sherlock, C ;

OShaughnessy, MV ;

Schechter, MT .

JOURNAL OF INFECTIOUS DISEASES, 1996, 174 (01) :191-194

[33]

Sabin CA, 2000, J ACQ IMMUN DEF SYND, V23, P172

[34] Turnover of CD4+ and CD8+ T lymphocytes in HIV-1 infection as measured by Ki-67 antigen [J].

Sachsenberg, N ;

Perelson, AS ;

Yerly, S ;

Schockmel, GA ;

Leduc, D ;

Hirschel, B ;

Perrin, L .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (08) :1295-1303

[35] Modeling plasma virus concentration during primary HIV infection [J].

Stafford, MA ;

Corey, L ;

Cao, YZ ;

Daar, ES ;

Ho, DD ;

Perelson, AS .

JOURNAL OF THEORETICAL BIOLOGY, 2000, 203 (03) :285-301

[36] Effect of immunization with a common recall antigen on viral expression in patients infected with human immunodeficiency virus type 1 [J].

Stanley, SK ;

Ostrowski, MA ;

Justement, JS ;

Gantt, K ;

Hedayati, S ;

Mannix, M ;

Roche, K ;

Schwartzentruber, DJ ;

Fox, CH ;

Fauci, AS .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (19) :1222-1230

[37] ACTIVATION OF VIRUS-REPLICATION AFTER VACCINATION OF HIV-1-INFECTED INDIVIDUALS [J].

STAPRANS, SI ;

HAMILTON, BL ;

FOLLANSBEE, SE ;

ELBEIK, T ;

BARBOSA, P ;

GRANT, RM ;

FEINBERG, MB .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (06) :1727-1737

[38] VIRAL DYNAMICS IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION [J].

WEI, XP ;

GHOSH, SK ;

TAYLOR, ME ;

JOHNSON, VA ;

EMINI, EA ;

DEUTSCH, P ;

LIFSON, JD ;

BONHOEFFER, S ;

NOWAK, MA ;

HAHN, BH ;

SAAG, MS ;

SHAW, GM .

NATURE, 1995, 373 (6510) :117-122

[39] Characterization of viral dynamics in human immunodeficiency virus type 1-infected patients treated with combination antiretroviral therapy: Relationships to host factors, cellular restoration, and virologic end points [J].

Wu, HL ;

Kuritzkes, DR ;

McClernon, DR ;

Kessler, H ;

Connick, E ;

Landay, A ;

Spear, G ;

Heath-Chiozzi, M ;

Rousseau, F ;

Fox, L ;

Spritzler, J ;

Leonard, JM ;

Lederman, MM .

JOURNAL OF INFECTIOUS DISEASES, 1999, 179 (04) :799-807

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