HSV-1 DNA Replication-Coordinated Regulation by Viral and Cellular Factors

被引：50

作者：

Packard, Jessica E. ^{[1
]}

Dembowski, Jill A. ^{[1
]}

机构：

[1] Duquesne Univ, Dept Biol Sci, Pittsburgh, PA 15282 USA

来源：

VIRUSES-BASEL | 2021年 / 13卷 / 10期

关键词：

herpes simplex virus; HSV-1; DNA replication; replication fork; recombination; SIMPLEX-VIRUS TYPE-1; ORIGIN-BINDING-PROTEIN; HERPESVIRUS MACROMOLECULAR-SYNTHESIS; MISMATCH REPAIR PROTEINS; HELICASE-PRIMASE; NUCLEAR ANTIGEN; POLYMERASE PROCESSIVITY; CATALYTIC SUBUNIT; ALKALINE NUCLEASE; THYMIDINE KINASE;

D O I：

10.3390/v13102015

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

DNA replication is an integral step in the herpes simplex virus type 1 (HSV-1) life cycle that is coordinated with the cellular DNA damage response, repair and recombination of the viral genome, and viral gene transcription. HSV-1 encodes its own DNA replication machinery, including an origin binding protein (UL9), single-stranded DNA binding protein (ICP8), DNA polymerase (UL30), processivity factor (UL42), and a helicase/primase complex (UL5/UL8/UL52). In addition, HSV-1 utilizes a combination of accessory viral and cellular factors to coordinate viral DNA replication with other viral and cellular processes. The purpose of this review is to outline the roles of viral and cellular proteins in HSV-1 DNA replication and replication-coupled processes, and to highlight how HSV-1 may modify and adapt cellular proteins to facilitate productive infection.

引用

页数：15

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