Synthesis of (±)-trans-2-[3-methoxy-4-(4 chlorophenylthioethoxy)-5-(N-methyl-N-hydroxyureidyl)methylphenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran

被引：0

作者：

Ram, B ^{[1
]}

Balram, B ^{[1
]}

Ram, SR ^{[1
]}

机构：

[1] Osmania Univ, Dept Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2003年 / 42卷 / 09期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of (+/-)-trans-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-(N-methyl-N-hydroxyureidyl)methylphenyl]-5-(3,4,5-trimethoxyphenyl) tetrahydrofuran from commercially available vanillin acetate and 3,4.5-trimethoxy benzaldehyde is reported.

引用

页码：2063 / 2068

页数：6

共 28 条

[1]

Batt D G, 1992, Prog Med Chem, V29, P1, DOI 10.1016/S0079-6468(08)70004-3

[2]

CAI X, 1994, 207 ACS M MARCH 13 1, P123

[3] (±)-trans-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-(N-methyl-N-hydroxyureidyl)methylphenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran (CMI-392), a potent dual 5-lipoxygenase inhibitor and platelet-activating factor receptor antagonist [J].

Cai, XO ;

Scannell, RT ;

Yaeger, D ;

Hussoin, MS ;

Killian, DB ;

Qian, CG ;

Eckman, J ;

Hwang, SB ;

Libertine-Garahan, L ;

Yeh, CG ;

Ip, SH ;

Shen, TY .

JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (11) :1970-1979

[4]

CARTER GW, 1991, J PHARMACOL EXP THER, V256, P929

[5] DESIGN OF PYRROLO-1,4-BENZOXAZINE DERIVATIVES AS INHIBITORS OF 5-LIPOXYGENASE AND PAF ANTAGONISTS WITH ANTIHISTAMINIC PROPERTIES [J].

DEMONCHAUX, P ;

LENOIR, P ;

AUGERT, G ;

DUPASSIEUX, P .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, 4 (20) :2383-2388

[6] LEUKOTRIENE-B, A POTENT CHEMOKINETIC AND AGGREGATING SUBSTANCE RELEASED FROM POLYMORPHONUCLEAR LEUKOCYTES [J].

FORDHUTCHINSON, AW ;

BRAY, MA ;

DOIG, MV ;

SHIPLEY, ME ;

SMITH, MJH .

NATURE, 1980, 286 (5770) :264-265

[7] DEVELOPMENT, SYNTHESIS, AND BIOLOGICAL EVALUATION OF (-)-TRANS-(2S,5S)-2-[3-[(2-OXOPROPYL)SULFONYL]-4-NORMAL-PROPOXY-5-(3-HYDROXYPROPOXY)-PHENYL]-5-(3,4,5-TRIMETHOXYPHENYL)TETRAHYDROFURAN, A POTENT ORALLY ACTIVE PLATELET-ACTIVATING-FACTOR (PAF) ANTAGONIST AND ITS WATER-SOLUBLE PRODRUG PHOSPHATE ESTER [J].

GIROTRA, NN ;

BIFTU, T ;

PONPIPOM, MM ;

ACTON, JJ ;

ALBERTS, AW ;

BACH, TN ;

BALL, RG ;

BUGIANESI, RL ;

PARSONS, WH ;

CHABALA, JC ;

DAVIES, P ;

DOEBBER, TW ;

DOHERTY, J ;

GRAHAM, DW ;

HWANG, SB ;

KUO, CH ;

LAM, MH ;

LUELL, S ;

MACINTYRE, DE ;

MEURER, R ;

ROBERTS, CD ;

SAHOO, SP ;

WU, MS .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (19) :3474-3482

[8]

GOLDSTEIN DM, 1992, MED CHEM RES, V2, P443

[9]

GOLDSTEIN DM, 1992, MED CHEM RES, V2, P451

[10] THE ROLE OF LEUKOTRIENES IN INFLAMMATION [J].

HENDERSON, WR .

ANNALS OF INTERNAL MEDICINE, 1994, 121 (09) :684-697

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