Cp*Co(III)-Catalyzed Regioselective Synthesis of Cyclopenta[b]carbazoles via Dual C(sp2)-H Functionalization of 1-(Pyridin-2-yl)-indoles with Diynes

被引：29

作者：

Li, Qiuyun ^{[1
]}

Wang, Yanwei ^{[1
]}

Li, Bin ^{[1
]}

Wang, Baiquan ^{[1
,2
,3
]}

机构：

[1] Nankai Univ, Coll Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

[2] Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 24期

基金：

中国国家自然科学基金;

关键词：

C-H ACTIVATION; OXIDATIVE ANNULATION; COUPLING REACTIONS; INTERNAL ALKYNES; INDOLE SYNTHESIS; CYCLIZATION; ACCESS; ARENES; CARBOCYCLIZATION; INTERMEDIATE;

D O I：

10.1021/acs.orglett.8b03438

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cp*Co(III)-catalyzed synthesis of cyclopenta [b-carbazoles from 1-(pyridin-2-yl)-indoles and diynes is developed. This reaction involves dual C-H activation of indoles and domino cyclizations with diynes and has excellent regioselectivity, high efficiency, a broad substrate scope, and tolerance for various functional groups. A series of cyclopenta[b]carbazole molecular scaffolds are obtained in good to excellent yields.

引用

页码：7884 / 7887

页数：4

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