Axial Length of Myopia: A Review of Current Research

被引：187
作者：
Meng, Weihua [1 ]
Butterworth, Jacqueline [1 ]
Malecaze, Francois [1 ,2 ,4 ]
Calvas, Patrick [1 ,3 ,4 ]
机构：
[1] Purpan Hosp, INSERM, U563, Physiopathol Ctr, FR-31024 Toulouse, France
[2] Purpan Hosp, Dept Ophthalmol, FR-31024 Toulouse, France
[3] Purpan Hosp, Dept Med Genet, FR-31024 Toulouse, France
[4] Univ Toulouse 3, F-31062 Toulouse, France
来源：
OPHTHALMOLOGICA | 2011年 / 225卷 / 03期
关键词：
Axial length; Myopia; Genetics; Refractive error; Endophenotype; ANTERIOR-CHAMBER DEPTH; COLLAGEN CROSS-LINKING; TERM BIOMECHANICAL PROPERTIES; REFRACTIVE-ERROR; OCULAR BIOMETRY; CORNEAL CURVATURE; RISK-FACTORS; INTRAOCULAR-PRESSURE; VISUAL IMPAIRMENT; SCLERAL COLLAGEN;
D O I：
10.1159/000317072
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Myopia, or nearsightedness, is a worldwide common type of refractive error. It is a non-life-threatening disorder with huge social and economic consequences due to its increasing prevalence. Axial length (AL) is the primary determinant of non-syndromic myopia. It is a parameter representing the combination of anterior chamber depth, lens thickness and vitreous chamber depth of the eye. AL can also be treated as an endophenotype of myopia and may provide extra advantages in the investigation of its genetic basis. The study of AL will not only identify the determinants of eye elongation, but also provide aetiological evidence for myopia. The purpose of this review is to outline the current state of AL research. Epidemiological evidence, genetic determinants, the relationship with other eye components and relative animal models of AL are summarised. Copyright (C) 2010 S. Karger AG, Basel
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收藏
页码：127 / 134
页数：8
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