Nonsteroidal anti-inflammatory drugs and cardiovascular disease risk in spondyloarthritis-spectrum diseases

被引：8

作者：

So, Ho ^{[1
]}

Tam, Lai-Shan ^{[1
]}

机构：

[1] Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Peoples R China

来源：

CURRENT OPINION IN RHEUMATOLOGY | 2022年 / 34卷 / 04期

关键词：

cardiovascular disease; nonsteroidal anti-inflammatory drugs; psoriatic arthritis; spondyloarthritis; NECROSIS-FACTOR INHIBITORS; ANKYLOSING-SPONDYLITIS; PSORIATIC-ARTHRITIS; COX-2; RECOMMENDATIONS; THERAPIES; MORTALITY; EVENTS;

D O I：

10.1097/BOR.0000000000000881

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of review Increased cardiovascular (CV) risk associated with nonsteroidal anti-inflammatory drugs (NSAIDs) is well recognized in the general population. This may limit the use of this effective therapy in patients with spondyloarthritis (SpA), a population already at high CV risk. Recent findings Increased CV diseases and their risk factors in patients with SpA were consistently shown in recent population-level data. NSAIDs remained commonly prescribed in SpA, though their structural benefit remained controversial and the dispensing practice was variable in different regions in the world. A previous observation study suggested NSAIDs in SpA might be cardio-protective, possibly via their modulation of the chronic inflammatory state. A recent meta-analysis of nonrandomized studies also revealed no increased risk of a CV event. Interestingly, there is growing evidence that different NSAIDs might impose differential CV risk on patients with SpA. Recent evidence suggested NSAIDs were associated with a neutral and possibly lower CV risk in patients with SpA, which provided some reassurance for their use.

引用

页码：203 / 208

页数：6

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