An Intermolecular Azidoheteroarylation of Simple Alkenes via Free-Radical Multicomponent Cascade Reactions

被引：73

作者：

Liu, Zhi ^{[1
]}

Liu, Zhong-Quan ^{[1
,2
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

[2] Nanjing Univ Chinese Med, Coll Pharm, State Key Lab Cultivat Base TCM Qual & Efficacy, Nanjing 210023, Jiangsu, Peoples R China

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 20期

基金：

中国国家自然科学基金;

关键词：

C-H ALKYLATION; PYRIDINE N-OXIDES; BETA-KETO-ESTERS; UNACTIVATED ALKENES; SODIUM TRIFLUOROMETHANESULFINATE; CATALYZED AZIDATION; CONVENIENT ACCESS; CENTERED RADICALS; REACTION SYSTEM; ORGANIC AZIDES;

D O I：

10.1021/acs.orglett.7b02788

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Based upon a radical polar effect, an intermolecular azidoheteroarylation of simple alkenes via a metal-free radical multi component cascade process was achieved. It allows a mild, rapid, and step economic access to a broad range of azidoalkylated heteroaromatics. Given the diversity in transformations of organic azides and medicinally privileged scaffolds of heteroarenes, this strategy enables efficient synthesis and late stage derivatization of drugs and candidates.

引用

页码：5649 / 5652

页数：4

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