Crystal structure of a mutant mineralocorticoid receptor responsible for hypertension

被引：101

作者：

Fagart, J

Huyet, J

Pinon, GM

Rochel, M

Mayer, C

Rafestin-Oblin, ME

机构：

[1] Univ Paris 07, INSERM, U478, F-75870 Paris, France

[2] Univ Paris 06, INSERM, U655, Lab Rech Mol Antibiot, F-75634 Paris, France

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2005年 / 12卷 / 06期

关键词：

D O I：

10.1038/nsmb939

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The S810L mutation within the human mineralocorticoid receptor (MR S810L) induces severe hypertension and switches progesterone from antagonist to agonist. Here we report the crystal structures of the ligand-binding domain of MR S810L in complex with progesterone and deoxycorticosterone, an agonist of both wild-type and mutant MRs. These structures, the first for MR, identify the specific contacts created by Leu810 and clarify the mechanism of activation of MR S810L.

引用

页码：554 / 555

页数：2

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