Histone deacetylase inhibitors: Overview and perspectives

被引：947

作者：

Dokmanovic, Milos ^{[1
]}

Clarke, Cathy ^{[1
]}

Marks, Paul A. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10021 USA

来源：

MOLECULAR CANCER RESEARCH | 2007年 / 5卷 / 10期

关键词：

D O I：

10.1158/1541-7786.MCR-07-0324

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Histone deacetylase inhibitors (HDACi) comprise structurally diverse compounds that are a group of targeted anticancer agents. The first of these new HDACi, vorinostat (suberoylanilide hydroxamic acid), has received Food and Drug Administration approval for treating patients with cutaneous T-cell lymphoma. This review focuses on the activities of the 11 zinc-containing HDACs, their histone and nonhistone protein substrates, and the different pathways by which HDACi induce transformed cell death. A hypothesis is presented to explain the relative resistance of normal cells to HDACi-induced cell death.

引用

页码：981 / 989

页数：9

共 116 条

[1] HDAC inhibitors as anti-inflammatory agents [J].

Adcock, I. M. .

BRITISH JOURNAL OF PHARMACOLOGY, 2007, 150 (07) :829-831

[2] Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90 - A novel basis for antileukemia activity of histone deacetylase inhibitors [J].

Bali, P ;

Pranpat, M ;

Bradner, J ;

Balasis, M ;

Fiskus, W ;

Guo, F ;

Rocha, K ;

Kumaraswamy, S ;

Boyapalle, S ;

Atadja, P ;

Seto, E ;

Bhalla, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (29) :26729-26734

[3] Acetylation of importin-α nuclear import factors by CBP/p300 [J].

Bannister, AJ ;

Miska, EA ;

Görlich, D ;

Kouzarides, T .

CURRENT BIOLOGY, 2000, 10 (08) :467-470

[4] Aminosuberoyl hydroxamic acids (ASHAs): A potent new class of HDAC inhibitors [J].

Belvedere, Sandro ;

Witter, David J. ;

Yan, Jiaming ;

Secrist, J. Paul ;

Richon, Victoria ;

Miller, Thomas A. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (14) :3969-3971

[5] Acetylation inactivates the transcriptional repressor BCL6 [J].

Bereshchenko, OR ;

Gu, W ;

Dalla-Favera, R .

NATURE GENETICS, 2002, 32 (04) :606-613

[6] Role of the tetradecapeptide repeat domain of human histone deacetylase 6 in cytoplasmic retention [J].

Bertos, NR ;

Gilquin, B ;

Chan, GKT ;

Yen, TJ ;

Khochbin, S ;

Yang, XJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (46) :48246-48254

[7] DNA damage-induced translocation of the Werner helicase is regulated by acetylation [J].

Blander, G ;

Zalle, N ;

Daniely, Y ;

Taplick, J ;

Gray, MD ;

Oren, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (52) :50934-50940

[8] Anticancer activities of histone deacetylase inhibitors [J].

Bolden, Jessica E. ;

Peart, Melissa J. ;

Johnstone, Ricky W. .

NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (09) :769-784

[9] Histone deacetylase activities are required for innate immune cell control of Th1 but not Th2 effector cell function [J].

Brogdon, Jennifer L. ;

Xu, Yongyao ;

Szabo, Susanne J. ;

An, Shaojian ;

Buxton, Francis ;

Cohen, Dalia ;

Huang, Qian .

BLOOD, 2007, 109 (03) :1123-1130

[10] Histone deacetylase inhibitors as therapeutics for polyglutamine disorders [J].

Butler, Rachel ;

Bates, Gillian P. .

NATURE REVIEWS NEUROSCIENCE, 2006, 7 (10) :784-796

← 1 2 3 4 5 6 7 8 9 10 →