Shape deformation of the insula in alcoholics: reduction of left-right asymmetry

被引：11
作者：
Jung, Young Chul
Jang, Dong-Pyo
Namkoong, Kee
Ku, Jeonghun
Kim, Jae-Jin
Park, Sangjin
Cho, Zang-Hee
Kim, Young-Bo
Lee, Eun [1 ]
机构：
[1] Natl Hlth Insurance Corp, Ilsan Hosp, Dept Psychiat, Suwon 410719, South Korea
[2] Yonsei Univ, Coll Med, Dept Psychiat, Seoul, South Korea
[3] Yonsei Univ, Coll Med, Inst Behav Sci Med, Suwon, South Korea
[4] Gachon Univ Med & Sci, Neurosci Res Inst, Inchon, South Korea
[5] Hanyang Univ, Dept Biomed Engn, Seoul 133791, South Korea
来源：
NEUROREPORT | 2007年 / 18卷 / 17期
关键词：
alcoholism; insula; left-right asymmetry; shape analysis;
D O I：
10.1097/WNR.0b013e3282f193b4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We have investigated shape deformation of the insula to get a viewpoint of how chronic alcohol consumption affects the perisylvian region and compared the deformity pattern between the left and right hemisphere. A landmark-based structural and surface shape analysis of the insula was performed in 20 patients with alcohol dependence and 20 controls matched for age. The shape analysis revealed that the left and right insula follow distinct shape deformation patterns, which resulted in the reduction of left-right asymmetry. The shape deformity was most prominent in the central part of both insula. Our findings indicate that the right and left hemisphere are both affected but shows distinct patterns of deformation in alcohol dependence.
引用
收藏
页码：1787 / 1791
页数：5
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