Overview of Orchestration of CD4+T Cell Subsets in Immune Responses

被引：43

作者：

Sun, Bing ^{[1
]}

Zhang, Yuan ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Cell Biol, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China

来源：

T HELPER CELL DIFFERENTIATION AND THEIR FUNCTION | 2014年 / 841卷

关键词：

CD4 T helper cell; Th cell subsets; Th1; Th2; Th17; REGULATORY T-CELLS; GROWTH-FACTOR-BETA; CXC CHEMOKINE RECEPTOR-5; FOLLICULAR-HELPER-CELLS; ROR-GAMMA-T; TGF-BETA; AUTOIMMUNE ENCEPHALOMYELITIS; TRANSCRIPTION FACTORS; AIRWAY INFLAMMATION; TH2; DIFFERENTIATION;

D O I：

10.1007/978-94-017-9487-9_1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Adaptive immunity plays an important role in the host defense of pathogens, among which CD4+ T helper cell takes a major part. The regulation of Th cell differentiation, the function they exerts in immune response, autoimmune diseases, and allergic conditions, has long attracted much attention. Naive CD4+ T cells differentiate into distinct subsets after receiving TCR and costimulation signaling for activation and cytokine signaling to direct their differentiation. In this chapter, we will have a broad overview of all Th cell subsets, including Th1, Th2, Th17, Treg, Tfh, as well as Th9 and Th22.

引用

页码：1 / 13

页数：13

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