Acute myeloid leukemia with multifineage dysplasia in children

被引：5

作者：

Adachi, Souichi ^{[1
]}

Manabe, Atsushi ^{[2
]}

Imaizumi, Masue ^{[3
]}

Taga, Takashi ^{[4
]}

Tawa, Akio ^{[5
]}

Tsurusawa, Masahito ^{[6
]}

Kikuchi, Akira ^{[7
]}

Masunaga, Atsuko ^{[8
]}

Tsuchida, Masahiro ^{[9
]}

Nakahata, Tatsutoshi ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Pediat, Sakyo Ku, Kyoto 6068507, Japan

[2] St Lukes Int Hosp, Dept Pediat, Tokyo, Japan

[3] Miyagi Childrens Hosp, Dept Hematol & Oncol, Miyagi, Japan

[4] Shiga Univ Med Sci, Dept Pediat, Shiga, Japan

[5] Osaka Natl Hosp, Natl Hosp Org, Dept Pediat, Osaka, Japan

[6] Aichi Med Univ, Dept Pediat, Aichi, Japan

[7] Saitama Childrens Med Ctr, Div Hematol Oncol, Saitama, Japan

[8] Showa Univ, Fujigaoka Hosp, Dept Surg Pathol, Kanagawa, Japan

[9] Ibaraki Childrens Hosp, Dept Pediat, Ibaraki, Japan

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2007年 / 86卷 / 04期

关键词：

AML with multilineage dysplasia; children; retrospective analysis;

D O I：

10.1532/IJH97.07025

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We retrospectively surveyed pediatric acute myeloid leukemia (AML) patients with multilineage dysplasia treated with the AML 99 and the Children's Cancer and Leukemia Study Group (CCLSG) AML 9805 protocols. We found only 9 AML patients (2.6%) with multilineage dysplasia among the 341 patients with newly diagnosed de novo AML. Eight of the 9 patients obtained complete remission (CR) following the intensive AML-oriented treatments. Three of 7 patients who underwent stem cell transplantation were alive in CR for more than 4 years, and the 2 patients treated only with chemotherapy were alive in CR for more than 30 months. We did not identify any particular chromosomal abnormalities or differentiation according to the French-American-British classification in these 9 patients. No reports have described AML with multilineage dysplasia in children, and the incidence of the disease is expected to be very low. We plan to conduct a prospective pathologic review to select cases with this disease entity in the next Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) AML-05 protocol.

引用

页码：358 / 363

页数：6

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