One Step Up in Antiproliferative Activity: The Ru-Zn Complex [RuCp(PPh3)2-μ-dmoPTA-1κP:2κ2N,N′-ZnCl2](CF3SO3)

被引：11

作者：

Mendoza, Zenaida ^{[1
]}

Lorenzo-Luis, Pablo ^{[1
]}

Scalambra, Franco ^{[2
]}

Padron, Jose M. ^{[3
]}

Romerosa, Antonio ^{[2
]}

机构：

[1] Univ La Laguna LL, Dept Quim Secc Quim Inorgan, San Cristobal la Laguna 38206, Spain

[2] Univ Almeria, Area Quim Inorgan, CIESOL, Carretera Sacramento S-N, Almeria, Spain

[3] Univ La Laguna, IUBO AG, BioLab, C Astrofis Francisco Sanchez 2, San Cristobal la Laguna 38206, Spain

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2018年 / 43期

关键词：

Antiproliferation; Cancer; Heterometallic complexes; PTA derivatives; Ruthenium; ARENE-RUTHENIUM(II) COMPLEXES; RUTHENIUM COMPLEXES; ANTICANCER; ACTIVATION; LIGANDS; DMOPTA; ZINC;

D O I：

10.1002/ejic.201800857

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis, characterization and antiproliferative activity of the bimetallic Ru-Zn complex [RuCp(PPh3)(2)-mu-dmoPTA-1 kappa P:2 kappa N-2,N '-ZnCl2](CF3SO3) (4) and the monometallic Ru complex [RuCp(PPh3)(2)(dmoPTA-1 kappa P)](CF3SO3) (5) are presented. Against human lung, cervix, breast, and colon solid tumor cell lines, complex 4 showed an enhanced antiproliferative activity (GI(50) = 30-83 nm) when compared to its parent complex [RuCp(PPh3)(2)(HdmoPTA-1 kappa P)](CF3SO3) (2). Additionally, it was significantly more active against the breast cancer cell line T-47D than its sibling cobalt complex [RuCp(PPh3)(2)-mu-dmoPTA-1 kappa P:2 kappa N-2,N '-CoCl2](CF3SO3) (3). When evaluated against non-tumor human cell line BJ-hTert, complex 4 was 3-8 times less active, indicating a large selectivity for tumor cells, while compound 5 was not selective.

引用

页码：4684 / 4688

页数：5

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