Changes in Gut Microbiota Induced by Doxycycline Influence in Vascular Function and Development of Hypertension in DOCA-Salt Rats

被引：17

作者：

Robles-Vera, Inaki ^{[1
,2
]}

de la Visitacion, Nestor ^{[1
,2
]}

Toral, Marta ^{[3
,4
]}

Sanchez, Manuel ^{[1
,2
,5
]}

Romero, Miguel ^{[1
,2
,5
]}

Gomez-Guzman, Manuel ^{[1
,2
,5
]}

Vargas, Felix ^{[5
,6
]}

Duarte, Juan ^{[1
,2
,4
,5
]}

Jimenez, Rosario ^{[1
,2
,4
,5
]}

机构：

[1] Univ Granada, Sch Pharm, Dept Pharmacol, Granada 18071, Spain

[2] Univ Granada, Ctr Biomed Res CIBM, Granada 18071, Spain

[3] Ctr Nacl Invest Cardiovasc CNI, Gene Regulat Cardiovasc Remodeling & Inflamma Grp, Madrid 28029, Spain

[4] CIBERCV, Madrid 28029, Spain

[5] Inst Invest Biosanitaria Granada, Granada 18012, Spain

[6] Univ Granada, Sch Med, Dept Physiol, Granada 18071, Spain

来源：

NUTRIENTS | 2021年 / 13卷 / 09期

关键词：

doxycycline; gut dysbiosis; hypertension; oxidative stress; inflammation; DOCA-salt model; NADPH OXIDASE ACTIVITY; BLOOD-PRESSURE; ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS; RECEPTOR; ANTIBIOTICS; ACTIVATION; DYSBIOSIS; PROTECTS; PREVENT;

D O I：

10.3390/nu13092971

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Previous experiments in animals and humans show that shifts in microbiota and its metabolites are linked to hypertension. The present study investigates whether doxycycline (DOX, a broad-spectrum tetracycline antibiotic) improves dysbiosis, prevent cardiovascular pathology and attenuate hypertension in deoxycorticosterone acetate (DOCA)-salt rats, a renin-independent model of hypertension. Male Wistar rats were randomly assigned to three groups: control, DOCA-salt hypertensive rats, DOCA-salt treated with DOX for 4 weeks. DOX decreased systolic blood pressure, improving endothelial dysfunction and reducing aortic oxidative stress and inflammation. DOX decreased lactate-producing bacterial population and plasma lactate levels, improved gut barrier integrity, normalized endotoxemia, plasma noradrenaline levels and restored the Treg content in aorta. These data demonstrate that DOX through direct effects on gut microbiota and its non-microbial effects (anti-inflammatory and immunomodulatory) reduces endothelial dysfunction and the increase in blood pressure in this low-renin form of hypertension.

引用

页数：17

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