Optical coherence tomography findings predictive of response to treatment in diabetic macular edema

被引:12
作者
Cho, Young Joo [1 ]
Lee, Dong Hyun [2 ]
Kim, Min [3 ]
机构
[1] HanGil Eye Hosp, Dept Ophthalmol, Incheon, South Korea
[2] Yonsei Univ, Coll Med, Severance Eye & ENT Hosp, Inst Vis Res,Dept Ophthalmol, Seoul, South Korea
[3] Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Ophthalmol, 211 Eonju Ro, Seoul 06273, South Korea
关键词
INTRAVITREAL TRIAMCINOLONE ACETONIDE; VITREOUS INFLAMMATORY FACTORS; BEVACIZUMAB; INJECTION; EYES; PATTERNS; RETINOPATHY; CYTOKINES; DEPENDS;
D O I
10.1177/0300060518798503
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Objective To evaluate the short-term efficacy of intravitreal bevacizumab (IVB) and posterior sub-tenon triamcinolone injections (PSTI) on the basis of spectral-domain optical coherence tomography (SD-OCT) patterns in diabetic macular edema (DME). Methods We retrospectively reviewed 73 eyes of 73 patients with DME. Based on the presence of serous retinal detachment (SRD), eyes were categorized into two groups, and either IVB or PSTI treatment was performed. Central macular thickness (CMT) and the degree of SRD were assessed preoperatively and 1 month postoperatively. The severity of intraretinal edema was approximated based on the distance from the external limiting membrane to the internal limiting membrane. Results In eyes with SRD, reduction of SRD was greater with IVB than with PSTI. Moreover, reduction of intraretinal edema was greater with PSTI than with IVB. In eyes without SRD, PSTI achieved greater CMT reduction, compared with IVB. Conclusions In DME patients with SRD, IVB achieved greater reduction of SRD, compared with PSTI; however, intraretinal edema responded more favorably to PSTI, regardless of the presence of SRD. Our results suggest that the classification of DME based on OCT findings may be useful to predict responses to IVB or PSTI treatments.
引用
收藏
页码:4455 / 4464
页数:10
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