Chemo-enzymatic synthesis of 3-deoxy-β-D-ribofuranosyl purines and study of their biological properties

被引：8

作者：

Barai, VN

Zinchenko, AI

Eroshevskaya, LA

Zhernosek, EV

Balzarini, J

De Clercq, E ^{[1
]}

Mikhailopulo, IA

机构：

[1] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium

[2] Natl Acad Sci, Inst Microbiol, Minsk, BELARUS

[3] Natl Acad Sci, Inst Bioorgan Chem, Minsk, BELARUS

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2003年 / 22卷 / 5-8期

关键词：

enzymatic transglycosylation; purine nucleosides; activity;

D O I：

10.1081/NCN-120022626

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

9-(3-Deoxy-beta-D-erythro-pentofuranosyl)-2,6-diiminopurine (2) was synthesized by an enzymatic transglycosylation of 2,6-diaminopurine using 3'-deoxycytidine (1) as a donor of the sugar moiety. Nucleoside 2 was transformed to 3'-deoxy guanosine (3), 9-(3-deoxy-beta-D-erythro-pentofuranosyl)-2-amino-6-oxopurine (3'-deoxyisoguanosine; 4), and 9-(3-deoxy-beta-D-erythro-pentofuranosyl)-2-fluoroadenine (5). Compounds 2-5 were evaluated for their anti-HIV activity.

引用

页码：751 / 753

页数：3

共 4 条

[1] MODIFIED NUCLEOSIDES .2. ECONOMICAL SYNTHESIS OF 2',3'-DIDEOXYCYTIDINE [J].