Phylogenomic analysis of SARS-CoV-2 from third wave clusters in Malaysia reveals dominant local lineage B.1.524 and persistent spike mutation A701V

被引：10

作者：

Suppiah, J. ^{[1
]}

Kamel, K. A. ^{[1
]}

Mohd-Zawawi, Z. ^{[1
]}

Afizan, M. A. ^{[1
]}

Yahya, H. ^{[2
]}

Md-Hanif, S. A. ^{[3
]}

Thayan, R. ^{[1
]}

机构：

[1] Minist Hlth Malaysia, Virol Unit, Infect Dis Res Ctr, Inst Med Res,Natl Inst Hlth, Shah Alam, Selangor, Malaysia

[2] Minist Hlth Malaysia, Fed Govt Adm Ctr, Disaster Outbreak Crisis & Emergency Management S, Surveillance Sect,Dis Control Div, Putrajaya, Malaysia

[3] Minist Hlth Malaysia, Fed Govt Adm Ctr, Int Travel & Hlth Regulat Sect, Surveillance Sect,Dis Control Div, Putrajaya, Malaysia

来源：

TROPICAL BIOMEDICINE | 2021年 / 38卷 / 03期

关键词：

COVID-19; phylogenomic; Malaysia; A701V; third wave; GENOME;

D O I：

10.47665/tb.38.3.070

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The emergence of a third wave of COVID-19 infection in Malaysia since September 2020 has led to imminent changes in public health prevention and control measures. As high as 96.2% of registered COVID-19 cases and 88.5% of confirmed deaths in Malaysia occurred during this third wave of infection. A phylogenomic study on 258 SARS-CoV-2 full genomes from February 2020-February 2021 has led to the discovery of a novel Malaysian lineage B.1.524. This lineage contains another spike mutation A701V that co-exists with the D614G spike mutation that was predominant in most of the third-wave clusters. The study provides vital genomic insights on the rapid spread of the SARS-CoV-2 variants in Malaysia in conjunction with the presence of a dominant SARS-CoV-2 lineage during the third wave of COVID-19 infection.

引用

页码：289 / 293

页数：5

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