Antimicrobial Peptides: The Promising Therapeutics for Cutaneous Wound Healing

被引：53
作者：
Miao, Fengze [1 ,2 ,3 ,4 ]
Li, Ying [1 ,2 ]
Tai, Zongguang [1 ,2 ]
Zhang, Yong [3 ,4 ]
Gao, Yue [3 ,4 ]
Hu, Menghong [1 ,2 ,3 ,4 ]
Zhu, Quangang [1 ,2 ]
机构：
[1] Tongji Univ, Sch Med, Shanghai Skin Dis Hosp, Shanghai 200443, Peoples R China
[2] Shanghai Engn Res Ctr Top Chinese Med, Shanghai 200443, Peoples R China
[3] Shanghai Ocean Univ, Minist Sci & Technol, Shanghai 201306, Peoples R China
[4] Shanghai Ocean Univ, Shanghai Engn Res Ctr Aquaculture, Shanghai 201306, Peoples R China
来源：
MACROMOLECULAR BIOSCIENCE | 2021年 / 21卷 / 10期
基金：
中国国家自然科学基金;
关键词：
antimicrobial peptides; bibliometrics; skin; wound dressings; wound healing; HOST-DEFENSE PEPTIDES; RESISTANT STAPHYLOCOCCUS-AUREUS; HUMAN CATHELICIDIN LL-37; FIBROBLAST-GROWTH-FACTOR; LIPID NANOPARTICLES SLN; HUMAN ALPHA-DEFENSIN; IN-VITRO; BACTERIAL CELLULOSE; KERATINOCYTE MIGRATION; DRUG-DELIVERY;
D O I：
10.1002/mabi.202100103
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chronic wound infections have caused an increasing number of deaths and economic burden, which necessitates wound treatment options. Hitherto, the development of functional wound dressings has achieved reasonable progress. Antibacterial agents, growth factors, and miRNAs are incorporated in different wound dressings to treat various types of wounds. As an effective antimicrobial agent and emerging wound healing therapeutic, antimicrobial peptides (AMPs) have attracted significant attention. The present study focuses on the application of AMPs in wound healing and discusses the types, properties and formulation strategies of AMPs used for wound healing. In addition, the clinical trial and the current status of studies on "antimicrobial peptides and wound healing" are elaborated through bibliometrics. Also, the challenges and opportunities for further development and utilization of AMP formulations in wound healing are discussed.
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页数：30
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