Fatty acid amide hydrolase: From characterization to therapeutics

被引：70
作者：
Labar, Geoffray
Michaux, Catherine
机构：
[1] Catholic Univ Louvain, Fac Med, Unite Chim Pharmaceut & Radiopharm, Ecole Pharm, B-1200 Brussels, Belgium
[2] Fac Univ Notre Dame Paix, Lab Chim Biol Structurale, Fac Sci, B-5000 Namur, Belgium
来源：
CHEMISTRY & BIODIVERSITY | 2007年 / 4卷 / 08期
关键词：
D O I：
10.1002/cbdv.200790157
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Fatty acid amide hydrolase (FAAH) is an integral membrane enzyme within the amidase-signature family that terminates the action of several endogenous lipid messengers, including oleamide and the endocannabinoid anandamide. The hydrolysis of such messengers leads to molecules devoid of biological activity, and, therefore, modulates a number of neurobehavioral processes in mammals, including pain, sleep, feeding, and locomotor activity. Investigations into the structure and function of FAAH, its biological and therapeutic implications, as well as a description of different families of FAAH inhibitors are the topic of this review.
引用
收藏
页码：1882 / 1902
页数：21
相关论文
共 119 条
[1]  
ABOUABDELLAH A, 2005, Patent No. 20050182130
[2]  
Abouabdellah A., 2006, U. S. Patent, Patent No. [2006/0089344 A1, 20060089344, US 2006/0089344]
[3]  
ABOUABDELLAH A, 2005, Patent No. 2864080
[4]   The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases [J].
Alexander, Jessica P. ;
Cravatt, Benjamin F. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (30) :9699-9704
[5]   Mechanism of carbamate inactivation of FAAH: Implications for the design of covalent inhibitors and in vivo functional probes for enzymes [J].
Alexander, JP ;
Cravatt, BF .
CHEMISTRY & BIOLOGY, 2005, 12 (11) :1179-1187
[6]  
Almario G.A., 2005, Abouabdellan A., Patent No. 2865205
[7]  
[Anonymous], 2004, Patent, Patent No. [2004033652A2, 2004033652]
[8]  
APODACA R, 2006, Patent No. 200674025
[9]   Deletion of a proline-rich region and a transmembrane domain in fatty acid amide hydrolase [J].
Arreaza, G ;
Deutsch, DG .
FEBS LETTERS, 1999, 454 (1-2) :57-60
[10]   Increased ethanol consumption and preference and decreased ethanol sensitivity in female FAAH knockout mice [J].
Basavarajappa, Balapal S. ;
Yalamanchili, Ratnakumar ;
Cravatt, Benjamin F. ;
Cooper, Thomas B. ;
Hungund, Basalingappa L. .
NEUROPHARMACOLOGY, 2006, 50 (07) :834-844
12345678910