A green chemical oligomerization of phloroglucinol induced by plasma as novel α-glucosidase inhibitors

被引：11

作者：

Choi, Soon Ho ^{[1
]}

Jeong, Gyeong Han ^{[2
]}

Lee, Kyung-Bon ^{[3
]}

Jo, Cheorun ^{[4
,5
]}

Kim, Tae Hoon ^{[2
]}

机构：

[1] Seoul Natl Univ, Dept Crop Sci & Biotechnol, Seoul, South Korea

[2] Daegu Univ, Dept Food Sci & Biotechnol, Gyongsan, South Korea

[3] Chonnam Natl Univ, Dept Biol Educ, Gwangju, South Korea

[4] Seoul Natl Univ, Ctr Food & Bioconvergence, Dept Agr Biotechnol, Seoul, South Korea

[5] Seoul Natl Univ, Res Inst Agr & Life Sci, Seoul, South Korea

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2018年 / 82卷 / 12期

基金：

新加坡国家研究基金会;

关键词：

Phloroglucinol; oligomerization; dielectric barrier discharge plasma; alpha-glucosidase; anti-diabetes; EISENIA-BICYCLIS; AGENTS; COMPLICATIONS;

D O I：

10.1080/09168451.2018.1516544

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new facile method was developed for simple green synthesis of methylene-bridged phloroglucinol oligomers using nonthermal dielectric barrier discharge (DBD) plasma in methanolic solution. The chemical structures of these newly generated oligomers 2-5 were determined by interpretation of the spectroscopic data, and the inhibitory activity toward alpha-glucosidase of all isolates was evaluated. The unusual phloroglcuinol pentamer 5 connected by four methylene linkages showed a much higher potential inhibitory effect against aglucosidase than the other generated oligomers 2-4 and appeared to be a promising lead for development as a potential antidiabetic agent.

引用

页码：2059 / 2063

页数：5

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