Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds

被引：68

作者：

Hoet, Sara

Pieters, Luc

Muccioli, Giulio G.

Habib-Jiwan, Jean-Louis

Opperdoes, Fred R.

Quetin-Leclercq, Joelle

机构：

[1] Univ Catholique Louvain, Lab Pharmacognosie, Unite Anal Chim & Physicochim Medicaments & Pharm, B-1200 Brussels, Belgium

[2] Univ Antwerp, Dept Pharmaceut Sci, Lab Pharmacognosy & Phytochem, B-2610 Antwerp, Belgium

[3] Univ Catholique Louvain, Unite Chim Pharmaceut & Radiopharm, B-1200 Brussels, Belgium

[4] Univ Catholique Louvain, Unite Chim Mat Inorgan & Organ, B-1348 Louvain, Belgium

[5] Univ Catholique Louvain, Trop Dis Res Unit, B-1200 Brussels, Belgium

[6] Univ Catholique Louvain, BCHM, Biochem Lab, B-1200 Brussels, Belgium

来源：

JOURNAL OF NATURAL PRODUCTS | 2007年 / 70卷 / 08期

关键词：

D O I：

10.1021/np070038q

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Fractionation of an antitrypanosomal lipophilic leaf extract from Strychnos spinosa led to the isolation of eight triterpenoids and sterols in this plant part for the first time. Two of these were found to possess in vitro antitrypanosomal activity, namely, saringosterol (14) and 24-hydroperoxy-24-vinylcholesterol (15), with IC50 values of 7.8 +/- 1.2 and 3.2 +/- 1.2 mu M, respectively. The latter compound was isolated from a plant source for the first time. A comparative study on the antitrypanosomal activity of the isolated triterpenoids and sterols and some related compounds has indicated that the presence of an oxygenated function at C-28 or an oxygenated side chain at C-17 seems to be important for the antitrypanosomal activity of triterpenoids and sterols, respectively.

引用

页码：1360 / 1363

页数：4

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