Glucose Oxidase-Polymer Nanogels for Synergistic Cancer-Starving and Oxidation Therapy

被引：163

作者：

Zhao, Wenguo ^{[1
]}

Hu, Jin ^{[1
]}

Gao, Weiping ^{[1
]}

机构：

[1] Tsinghua Univ, Sch Med, Dept Biomed Engn, Beijing 100084, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2017年 / 9卷 / 28期

基金：

中国国家自然科学基金;

关键词：

glucose oxidase; nanogel; protein-polymer conjugate; cancer therapy; synergistic therapy; HYDROGEN-PEROXIDE; APOPTOSIS; RELEASE; TUMORS; CELLS; NANOPARTICLES; ACTIVATION; GENERATION; INVIVO; SYSTEM;

D O I：

10.1021/acsami.7b06814

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Glucose oxidase (GOX) can convert glucose into gluconic acid and hydrogen peroxide (H2O2), which is potentially useful for synergistic cancer-starving and oxidation therapy. Herein we demonstrate a glucose-responsive nano medicine made of GOX polymer nanogels to regulate H2O2 production for synergistic melanoma starving and oxidation therapy. GOX polymer nanogels showed glucose-responsive H2O2-generating activity in vitro, improved stability, and considerably enhanced tumor retention as compared to native GOX. More importantly, they exhibited high antimelanoma efficacy and no obvious systemic toxicity, whereas native GOX was ineffective and systemically toxic at the same dose. This work paves the way for establishing an endogenous and noninvasive cancer treatment paradigm that is based on intratumoral glucose-responsive, H2O2-generating chemical reactions.

引用

页码：23528 / 23535

页数：8

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