ARID1A upregulation predicts better survival in patients with urothelial bladder carcinoma

被引：9

作者：

Cao, Qifeng ^{[1
]}

Wang, Chen ^{[1
]}

Ding, Yu ^{[1
]}

Xu, Ding ^{[1
]}

Qian, Subo ^{[1
]}

Shen, Haibo ^{[1
]}

Qi, Jun ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Xin Hua Hosp, Dept Urol, Shanghai 200092, Peoples R China

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2019年

关键词：

ARID1A; bladder cancer; tumor suppressor; proliferation; migration; prognosis; REMODELING GENE ARID1A; TUMOR-SUPPRESSOR; FREQUENT MUTATIONS; SOMATIC MUTATIONS; CLEAR-CELL; CANCER; EXPRESSION; ADENOCARCINOMA; COMPLEXES;

D O I：

10.1177/0300060519895687

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objective AT-rich interactive domain-containing protein 1A (ARID1A) is frequently mutated or deficient in various types of tumors. However, the role of ARID1A in bladder cancer remains unclear. We aimed to evaluate ARID1A expression and its biological role and correlation with prognosis in patients with urothelial bladder carcinoma (BUC). Methods ARID1A expression levels in BUC and normal tissues were assessed by immunohistochemistry and correlated with clinicopathological characteristics and patient outcomes. Downregulation of ARID1A was mimicked by transfection with small interfering RNA in T24 bladder cancer cells, and the effects on cell proliferation and migration were evaluated. Results ARID1A expression was significantly reduced in BUC tissues and was significantly associated with T stage and AJCC stage. Upregulation of ARID1A predicted a better prognosis in BUC patients. ARID1A expression and lymph node status were identified as independent prognostic factors for overall survival. Silencing of ARID1A promoted the proliferation of BUC cells. Conclusions ARID1A may represent a novel diagnostic and prognostic biomarker in patients with BUC.

引用

页数：10

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