Post Orgasmic Illness Syndrome (POIS) and Delayed Onset Muscle Soreness (DOMS): Do They Have Anything in Common?

被引:32
作者
Sonkodi, Balazs [1 ]
Kopa, Zsolt [2 ]
Nyirady, Peter [2 ]
机构
[1] Univ Phys Educ, Dept Hlth Sci & Sport Med, H-1123 Budapest, Hungary
[2] Semmelweis Univ, Dept Urol, H-1082 Budapest, Hungary
关键词
post orgasmic illness syndrome; delayed onset muscle soreness; repeated bout effect; muscle spindle; Piezo 2 ion channel; acute compression proprioceptive axonopathy; ECCENTRIC EXERCISE; MEMORY; MODULATION; OXYTOCIN; SYSTEM; BULBOSPONGIOSUS; INVOLVEMENT; POLYAMINES; SPERMIDINE; CONTRIBUTE;
D O I
10.3390/cells10081867
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Post orgasmic illness syndrome is a rare, mysterious condition with an unknown pathomechanism and uncertain treatment. The symptoms of post orgasmic illness syndrome last about 2-7 days after an ejaculation. The current hypothesis proposes that the primary injury in post orgasmic illness syndrome is an acute compression proprioceptive axonopathy in the muscle spindle, as is suspected in delayed onset muscle soreness. The terminal arbor degeneration-like lesion of delayed onset muscle soreness is theorized to be an acute stress response energy-depleted dysfunctional mitochondria-induced impairment of Piezo2 channels and glutamate vesicular release. The recurring symptoms of post orgasmic illness syndrome after each ejaculation are suggested to be analogous to the repeated bout effect of delayed onset muscle soreness. However, there are differences in the pathomechanism, mostly attributed to the extent of secondary tissue damage and to the extent of spermidine depletion. The spermidine depletion-induced differences are as follows: modulation of the acute stress response, flu-like symptoms, opioid-like withdrawal and enhanced deregulation of the autonomic nervous system. The longitudinal dimension of delayed onset muscle soreness, in the form of post orgasmic illness syndrome and the repeated bout effect, have cognitive and memory consequences, since the primary injury is learning and memory-related.
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页数:11
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