Stabilization of Hoogsteen base pairing by introduction of NH2 group at the C8 position of adenine

被引：22

作者：

Kawai, K

Saito, I ^{[1
]}

Sugiyama, H

机构：

[1] Kyoto Univ, Grad Sch Engn, Dept Synthet & Biol Chem, Kyoto 6068501, Japan

[2] Tokyo Med & Dent Univ, Inst Med & Dent Engn, Tokyo 1010061, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 29期

关键词：

D O I：

10.1016/S0040-4039(98)01026-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 8-aminodeoxyadenosine containing oligonucleotides has been described. The incorporation of an amino group at the C8 position of adenine greatly stabilized the Hoogsteen base pairing in tripler formation. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：5221 / 5224

页数：4

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