共 138 条
Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo
被引:500
作者:

Villadangos, Jose A.
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机构: Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

Schnorrer, Petra
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h-index: 0
机构: Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
机构:
[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
[2] Deutsch Krebsforschungszentrum, D-69120 Heidelberg, Germany
基金:
英国医学研究理事会;
关键词:
D O I:
10.1038/nri2103
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Dendritic cells (DCs) comprise several subsets, and their roles in the presentation of antigens derived from pathogens, vaccines and self tissues are now beginning to be elucidated. Differences in location, life cycle and intrinsic abilities to capture, process and present antigens on their MHC class I and class II molecules enable each DC subset to have distinct roles in immunity to infection and in the maintenance of self tolerance. Unexpected interactions among DC subsets have also been revealed. These interactions, which allow the integration of the intrinsic abilities of different DC types, enhance the ability of the DC network to respond to multiple scenarios of infection.
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页码:543 / 555
页数:13
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