Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo

被引:500
作者
Villadangos, Jose A.
Schnorrer, Petra
机构
[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
[2] Deutsch Krebsforschungszentrum, D-69120 Heidelberg, Germany
基金
英国医学研究理事会;
关键词
D O I
10.1038/nri2103
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Dendritic cells (DCs) comprise several subsets, and their roles in the presentation of antigens derived from pathogens, vaccines and self tissues are now beginning to be elucidated. Differences in location, life cycle and intrinsic abilities to capture, process and present antigens on their MHC class I and class II molecules enable each DC subset to have distinct roles in immunity to infection and in the maintenance of self tolerance. Unexpected interactions among DC subsets have also been revealed. These interactions, which allow the integration of the intrinsic abilities of different DC types, enhance the ability of the DC network to respond to multiple scenarios of infection.
引用
收藏
页码:543 / 555
页数:13
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共 138 条
[91]   Cross-presentation: underlying mechanisms and role in immune surveillance [J].
Rock, KL ;
Shen, L .
IMMUNOLOGICAL REVIEWS, 2005, 207 :166-183
[92]   Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells [J].
Rodriguez, A ;
Regnault, A ;
Kleijmeer, M ;
Ricciardi-Castagnoli, P ;
Amigorena, S .
NATURE CELL BIOLOGY, 1999, 1 (06) :362-368
[93]   Efficient Presentation of Soluble Antigen by Cultured Human Dendritic Cells Is Maintained by Granulocyte/Macrophage Colony-stimulating Factor Plus Interleukin 4 and Downregulated by Tumor Necrosis Factor α [J].
Sallusto, Federica ;
Lanzavecchia, Antonio .
JOURNAL OF IMMUNOLOGY, 2018, 200 (03) :887-896
[94]   NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells [J].
Savina, Ariel ;
Jancic, Carolina ;
Hugues, Stephanie ;
Guermonprez, Pierre ;
Vargas, Pablo ;
Moura, Ivan Cruz ;
Lennon-Dumenil, Ana-Maria ;
Seabra, Miguel C. ;
Raposo, Graca ;
Amigorena, Sebastian .
CELL, 2006, 126 (01) :205-218
[95]   Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node [J].
Scheinecker, C ;
McHugh, R ;
Shevach, EM ;
Germain, RN .
JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (08) :1079-1090
[96]   The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture [J].
Schnorrer, Petra ;
Behrens, Georg M. N. ;
Wilson, Nicholas S. ;
Pooley, Joanne L. ;
Smith, Christopher M. ;
EI-Sukkari, Dima ;
Davey, Gayle ;
Kupresanin, Fiona ;
Li, Ming ;
Maraskovsky, Eugene ;
Belz, Gabrielle T. ;
Carbone, Francis R. ;
Shortman, Ken ;
Heath, William R. ;
Villadangos, Jose A. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (28) :10729-10734
[97]   Cross-presentation of cell-associated antigens by CD8α+ dendritic cells is attributable to their ability to internalize dead cells [J].
Schulz, O ;
Sousa, CRE .
IMMUNOLOGY, 2002, 107 (02) :183-189
[98]   TN/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection [J].
Serbina, NV ;
Salazar-Mather, TP ;
Biron, CA ;
Kuziel, WA ;
Pamer, EG .
IMMUNITY, 2003, 19 (01) :59-70
[99]   Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo [J].
Shen, LJ ;
Sigal, LJ ;
Boes, M ;
Rock, KL .
IMMUNITY, 2004, 21 (02) :155-165
[100]   Steady-state and inflammatory dendritic-cell development [J].
Shortman, Ken ;
Naik, Shalin H. .
NATURE REVIEWS IMMUNOLOGY, 2007, 7 (01) :19-30