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Diastereo- and enantio-selective synthesis of 6-heterosubstituted-3,5-dihydroxyesters: Novel precursors of mevinolin analogues
被引：16
|作者：
Enders, D
Burkamp, F
Runsink, J
机构：
[1] Institut für Organische Chemie, Rheinisch-Westfälische TH, 52074 Aachen
关键词：
D O I：
10.1039/cc9960000609
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The diastereoselective addition of 1,3-bis(trimethylsilyloxy)-1-methoxybutadiene 2 to readily available alpha-heterosubstituted aldehydes (S)-1 affords after syn-diastereoselective reduction HMG-CoA-reductase-inhibitor-precursors (S,R,S)-4 and 5 with various substitution patterns and high enantiomeric and diastereoisomeric excesses (ee = 93- > 96%; de 95- > 96%) in good yields.
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页码：609 / 610
页数：2
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