China's flourishing synthetic organofluorine chemistry: innovations in the new millennium

被引:149
作者
Liu, Qinghe [1 ]
Ni, Chuanfa [1 ]
Hu, Jinbo [1 ]
机构
[1] Chinese Acad Sci, Key Lab Organofluorine Chem, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China
基金
中国国家自然科学基金;
关键词
fluorine; organic chemistry; synthetic methods; fluorination; trifluoromethylation; trifluoromethylthiolation; difluoromethylation; difluoroalkylation; fluoromethylation; fluoroolefination; C-F BOND; COPPER-CATALYZED TRIFLUOROMETHYLATION; ARYL BORONIC ACIDS; ALPHA; BETA-UNSATURATED CARBOXYLIC-ACIDS; MEDIATED OXIDATIVE TRIFLUOROMETHYLATION; HIGHLY ENANTIOSELECTIVE CONSTRUCTION; ELECTRON-DEFICIENT POLYFLUOROARENES; CARBON-FLUORINE BOND; ALPHA-DIAZO ESTERS; ONE-POT SYNTHESIS;
D O I
10.1093/nsr/nwx058
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The new millennium has witnessed the rapid development of synthetic organofluorine chemistry all over the world, and chemists in China have made significant contributions in this field. This review aims to provide a brief introduction to China's primary innovations from 2000 to early 2017, covering fluorination, fluoroalkylation, fluoromethylthiolation, fluoroolefination and polyfluoroarylation, as well as synthesis with fluorinated building blocks. Recent advances in the chemistry of difluorocarbene and the chemistry of carbon-fluorine bond activation are also discussed. As a conclusion, the review ends with some personal perspectives on the future development of China's synthetic organofluorine chemistry.
引用
收藏
页码:303 / 325
页数:23
相关论文
共 274 条
  • [1] Functionalization of Fluorinated Molecules by Transition-Metal-Mediated C-F Bond Activation To Access Fluorinated Building Blocks
    Ahrens, Theresia
    Kohlmann, Johannes
    Ahrens, Mike
    Braun, Thomas
    [J]. CHEMICAL REVIEWS, 2015, 115 (02) : 931 - 972
  • [2] Carbon Trifluoromethylation Reactions of Hydrocarbon Derivatives and Heteroarenes
    Alonso, Concepcion
    Martinez de Marigorta, Eduardo
    Rubiales, Gloria
    Palacios, Francisco
    [J]. CHEMICAL REVIEWS, 2015, 115 (04) : 1847 - 1935
  • [3] Facile Access to Fluoromethylated Arenes by Nickel-Catalyzed Cross-Coupling between Arylboronic Acids and Fluoromethyl Bromide
    An, Lun
    Xiao, Yu-Lan
    Min, Qiao-Qiao
    Zhang, Xingang
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015, 54 (31) : 9079 - 9083
  • [4] Fluorinated sulfoximines: syntheses, properties and applications
    Bizet, Vincent
    Kowalczyk, Rafal
    Bolm, Carsten
    [J]. CHEMICAL SOCIETY REVIEWS, 2014, 43 (08) : 2426 - 2438
  • [5] Modern Carbon-Fluorine Bond Forming Reactions for Aryl Fluoride Synthesis
    Campbell, Michael G.
    Ritter, Tobias
    [J]. CHEMICAL REVIEWS, 2015, 115 (02) : 612 - 633
  • [6] DIFLUOROIODOMETHANE - PRACTICAL SYNTHESIS AND REACTION WITH ALKENES
    CAO, P
    DUAN, JX
    CHEN, QY
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1994, (06) : 737 - 738
  • [7] Monofluorination of Organic Compounds: 10 Years of Innovation
    Champagne, Pier Alexandre
    Desroches, Justine
    Hamel, Jean-Denys
    Vandamme, Mathilde
    Paquin, Jean-Francois
    [J]. CHEMICAL REVIEWS, 2015, 115 (17) : 9073 - 9174
  • [8] Pd-Catalyzed Difluoromethylation of Vinyl Bromides, Triflates, Tosylates, and Nonaflates
    Chang, Dalu
    Gu, Yang
    Shen, Qilong
    [J]. CHEMISTRY-A EUROPEAN JOURNAL, 2015, 21 (16) : 6074 - 6078
  • [9] A direct catalytic ring expansion approach to o-fluoronaphthols and o/p-fluorophenols from indanones and 2-cyclopentenones
    Chang, Jian
    Song, Xiaoning
    Huang, Wanqiao
    Zhu, Dongsheng
    Wang, Mang
    [J]. CHEMICAL COMMUNICATIONS, 2015, 51 (84) : 15362 - 15365
  • [10] Electrophilic Trifluoromethylation by Use of Hypervalent Iodine Reagents
    Charpentier, Julie
    Frueh, Natalja
    Togni, Antonio
    [J]. CHEMICAL REVIEWS, 2015, 115 (02) : 650 - 682