Implication of EEG theta/alpha and theta/beta ratio in Alzheimer's and Lewy body disease

被引：35

作者：

Baik, Kyoungwon ^{[1
]}

Jung, Jin Ho ^{[1
]}

Jeong, Seong Ho ^{[1
]}

Chung, Seok Jong ^{[1
]}

Yoo, Han Soo ^{[1
]}

Lee, Phil Hyu ^{[1
]}

Sohn, Young H. ^{[1
]}

Kang, Seung Wan ^{[2
,3
]}

Ye, Byoung Seok ^{[1
]}

机构：

[1] Yonsei Univ, Dept Neurol, Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea

[2] iMediSync Inc, Seoul, South Korea

[3] Seoul Natl Univ, Coll Nursing, Data Ctr Korean EEG, Seoul, South Korea

来源：

SCIENTIFIC REPORTS | 2022年 / 12卷 / 01期

关键词：

MILD COGNITIVE IMPAIRMENT; NEURAL SYNCHRONIZATION MECHANISMS; PARKINSONS-DISEASE; QUANTITATIVE EEG; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; CHOLINERGIC SYSTEM; NATIONAL INSTITUTE; ALPHA-SYNUCLEIN; USEFUL TOOL;

D O I：

10.1038/s41598-022-21951-5

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We evaluated the patterns of quantitative electroencephalography (EEG) in patients with Alzheimer's disease (AD), Lewy body disease (LBD), and mixed disease. Sixteen patients with AD, 38 with LBD, 20 with mixed disease, and 17 control participants were recruited and underwent EEG. The theta/alpha ratio and theta/beta ratio were measured. The relationship of the log-transformed theta/alpha ratio (TAR) and theta/beta ratio (TBR) with the disease group, the presence of AD and LBD, and clinical symptoms were evaluated. Participants in the LBD and mixed disease groups had higher TBR in all lobes except for occipital lobe than those in the control group. The presence of LBD was independently associated with higher TBR in all lobes and higher central and parietal TAR, while the presence of AD was not. Among cognitively impaired patients, higher TAR was associated with the language, memory, and visuospatial dysfunction, while higher TBR was associated with the memory and frontal/executive dysfunction. Increased TBR in all lobar regions and temporal TAR were associated with the hallucinations, while cognitive fluctuations and the severity of Parkinsonism were not. Increased TBR could be a biomarker for LBD, independent of AD, while the presence of mixed disease could be reflected as increased TAR.

引用

页数：12

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