Replication of N2,3-Ethenoguanine by DNA Polymerases

被引：30

作者：

Zhao, Linlin ^{[1
,2
]}

Christov, Plamen P. ^{[3
,4
]}

Kozekov, Ivan D. ^{[3
,4
]}

Pence, Matthew G. ^{[1
,2
]}

Pallan, Pradeep S. ^{[1
,2
]}

Rizzo, Carmelo J. ^{[5
]}

Egli, Martin ^{[1
,2
]}

Guengerich, F. Peter ^{[1
,2
]}

机构：

[1] Vanderbilt Univ, Dept Biochem, Sch Med, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Ctr Mol Toxicol, Sch Med, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Sch Med, Dept Chem, Nashville, TN 37235 USA

[4] Vanderbilt Univ, Sch Med, Ctr Mol Toxicol, Nashville, TN 37235 USA

[5] Vanderbilt Univ, Dept Biochem, Nashville, TN 37235 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 22期

关键词：

DNA damage; DNA polymerases; DNA replication; DNA structures; mutagenesis; VINYL-CHLORIDE; ESCHERICHIA-COLI; MISCODING PROPERTIES; MASS-SPECTROMETRY; ADDUCTS; N-2-ETHENOGUANINE; LESION; OLIGONUCLEOTIDES; MISINCORPORATION; AGENTS;

D O I：

10.1002/anie.201109004

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Damaged goods: The unstable DNA adduct N 2,3-ethenoguanine, a product of both exposure to the carcinogen vinyl chloride and of oxidative stress, was built into an oligonucleotide, using an isostere strategy to stabilize the glycosidic bond. This modification was then used to examine the cause of mutations by DNA polymerases, in terms of both the biochemistry of the lesion and a structure of the lesion within a polymerase (see scheme). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：5466 / 5469

页数：4

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