Well-Defined, Reversible Boronate Crosslinked Nanocarriers for Targeted Drug Delivery in Response to Acidic pH Values and cis-Diols

被引：345
作者：
Li, Yuanpei [2 ]
Xiao, Wenwu [2 ]
Xiao, Kai [2 ]
Berti, Lorenzo [2 ]
Luo, Juntao [1 ]
Tseng, Harry P. [2 ]
Fung, Gabriel [2 ]
Lam, Kit S. [2 ]
机构：
[1] SUNY Upstate Med Univ, Dept Pharmacol, SUNY Upstate Canc Res Inst, Syracuse, NY 13210 USA
[2] Univ Calif Davis, Dept Biochem & Mol Med, UC Davis Canc Ctr, Sacramento, CA 95817 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 12期
关键词：
boronate; controlled release; FRET; micelles; nanocarriers; PACLITAXEL DELIVERY; MICELLES; NANOPARTICLES; RELEASE;
D O I：
10.1002/anie.201107144
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Demand and deliver: Micelles reversibly crosslinked by boronate esters (see scheme) show in vitro and in vivo stability, and thus minimize premature drug release under physiological conditions. After reaching the tumor sites, drug (stars in scheme) release is activated by cleavage of the boronate esters by the acidic conditions around the tumor or in the target cells, or by the administration of mannitol. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：2864 / 2869
页数：6
相关论文
共 52 条
  • [1] [Anonymous], 2009, ANGEW CHEM
  • [2] Boronic acid-functionalized nanoparticles: synthesis by microemulsion polymerization and application as a re-usable optical nanosensor for carbohydrates
    Cannizzo, C
    Amigoni-Gerbier, S
    Larpent, C
    [J]. POLYMER, 2005, 46 (04) : 1269 - 1276
  • [3] Chaikof E. L., 2010, ANGEW CHEM INT EDIT, V49, P4257
  • [4] Chaikof E. L., 2010, ANGEW CHEM, V122, P4353
  • [5] Release of hydrophobic molecules from polymer micelles into cell membranes revealed by Forster resonance energy transfer imaging
    Chen, Hongtao
    Kim, Sungwon
    Li, Li
    Wang, Shuyi
    Park, Kinam
    Cheng, Ji-Xin
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (18) : 6596 - 6601
  • [6] Fast release of lipophilic agents from circulating PEG-PDLLA micelles revealed by in vivo Forster resonance energy transfer imaging
    Chen, Hongtao
    Kim, Sungwon
    He, Wei
    Wang, Haifeng
    Low, Philip S.
    Park, Kinam
    Cheng, Ji-Xin
    [J]. LANGMUIR, 2008, 24 (10) : 5213 - 5217
  • [7] Intracellularly monitoring/imaging the release of doxorubicin from pH-responsive nanoparticles using Forster resonance energy transfer
    Chen, Ko-Jie
    Chiu, Ya-Ling
    Chen, Yu-Ming
    Ho, Yi-Cheng
    Sung, Hsing-Wen
    [J]. BIOMATERIALS, 2011, 32 (10) : 2586 - 2592
  • [8] Cheng J. X., 2010, EXPERT OPIN DRUG DEL, V7, P49
  • [9] Dai J., 2011, ANGEW CHEM, V123, P9576
  • [10] Interlayer-Crosslinked Micelle with Partially Hydrated Core Showing Reduction and pH Dual Sensitivity for Pinpointed Intracellular Drug Release
    Dai, Jian
    Lin, Shudong
    Cheng, Du
    Zou, Seyin
    Shuai, Xintao
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (40) : 9404 - 9408
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