Well-Defined, Reversible Boronate Crosslinked Nanocarriers for Targeted Drug Delivery in Response to Acidic pH Values and cis-Diols

被引：349

作者：

Li, Yuanpei ^{[2
]}

Xiao, Wenwu ^{[2
]}

Xiao, Kai ^{[2
]}

Berti, Lorenzo ^{[2
]}

Luo, Juntao ^{[1
]}

Tseng, Harry P. ^{[2
]}

Fung, Gabriel ^{[2
]}

Lam, Kit S. ^{[2
]}

机构：

[1] SUNY Upstate Med Univ, Dept Pharmacol, SUNY Upstate Canc Res Inst, Syracuse, NY 13210 USA

[2] Univ Calif Davis, Dept Biochem & Mol Med, UC Davis Canc Ctr, Sacramento, CA 95817 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 12期

关键词：

boronate; controlled release; FRET; micelles; nanocarriers; PACLITAXEL DELIVERY; MICELLES; NANOPARTICLES; RELEASE;

D O I：

10.1002/anie.201107144

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Demand and deliver: Micelles reversibly crosslinked by boronate esters (see scheme) show in vitro and in vivo stability, and thus minimize premature drug release under physiological conditions. After reaching the tumor sites, drug (stars in scheme) release is activated by cleavage of the boronate esters by the acidic conditions around the tumor or in the target cells, or by the administration of mannitol. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：2864 / 2869

页数：6

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