A potential explanation of some established major risk factors for autism

被引:13
作者
James, William H. [1 ]
机构
[1] UCL, Galton Lab, Dept Genet Evolut & Environm, London, England
关键词
PARENTAL HORMONE-LEVELS; MAMMALIAN SEX-RATIOS; ANDROGEN LEVELS; SPECTRUM DISORDERS; GROWTH-RETARDATION; DIGIT RATIO; TESTOSTERONE; BIRTH; PREGNANCY; TIME;
D O I
10.1111/j.1469-8749.2012.04225.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
BaronCohen hypothesized that a cause of autism in infants is exposure to high concentrations of intrauterine testosterone concentrations. Some of the subsequent research on this hypothesis has focused on the possibility that the source of this testosterone is the fetus; however, this review shows that if the source is taken to be the mother, then many of the established risk factors for autism could be explained. If that were correct, it would follow that high maternally derived intrauterine androgen concentrations may be a major environmental cause of autism.
引用
收藏
页码:301 / 305
页数:5
相关论文
共 59 条
[41]   The 2nd to 4th digit ratio and autism [J].
Manning, JT ;
Baron-Cohen, S ;
Wheelwright, S ;
Sanders, G .
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY, 2001, 43 (03) :160-164
[42]   The sex ratio of siblings of individuals with a history of developmental language disorder [J].
Mouridsen, Svend Erik ;
Hauschild, Karen-Marie .
LOGOPEDICS PHONIATRICS VOCOLOGY, 2010, 35 (03) :144-148
[43]   Sibling sex ratio of individuals diagnosed with autism spectrum disorder as children [J].
Mouridsen, Svend Erik ;
Rich, Bente ;
Isager, Torben .
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY, 2010, 52 (03) :289-292
[44]   Physiologic markers of chronic stress in premenopausal, middle-aged women [J].
Powell, LH ;
Lovallo, WR ;
Matthews, KA ;
Meyer, P ;
Midgley, AR ;
Baum, A ;
Stone, AA ;
Underwood, L ;
McCann, JJ ;
Herro, KJ ;
Ory, MG .
PSYCHOSOMATIC MEDICINE, 2002, 64 (03) :502-509
[45]   Altered prefrontal cortical function during processing of fear-relevant stimuli in pregnancy [J].
Roos, Annerine ;
Robertson, Frances ;
Lochner, Christine ;
Vythilingum, Bavanisha ;
Stein, Dan J. .
BEHAVIOURAL BRAIN RESEARCH, 2011, 222 (01) :200-205
[46]   Commentary: Fact and artefact in the secular increase in the rate of autism [J].
Rutter, Michael .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2009, 38 (05) :1238-1239
[47]   Breastfeeding, infant formula supplementation, and Autistic Disorder: The results of a parent survey [J].
Schultz S.T. ;
Klonoff-Cohen H.S. ;
Wingard D.L. ;
Akshoomoff N.A. ;
Macera C.A. ;
Ji M. ;
Bacher C. .
International Breastfeeding Journal, 1 (1)
[48]   Androgen levels of preeclamptic patients in the third trimester of pregnancy and six weeks after delivery [J].
Serin, IS ;
Kula, M ;
Basbug, M ;
Ünlühizarci, KA ;
Güçer, S ;
Tayyar, M .
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 2001, 80 (11) :1009-1013
[49]   Toward localizing genes underlying cerebral asymmetry and mental health [J].
Smalley, SL ;
Loo, SK ;
Yang, MH ;
Cantor, RM .
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2005, 135B (01) :79-84
[50]   Fetal programming: Prenatal testosterone treatment causes intrauterine growth retardation, reduces ovarian reserve and increases ovarian follicular recruitment [J].
Steckler, T ;
Wang, JR ;
Bartol, FF ;
Roy, SK ;
Padmanabhan, V .
ENDOCRINOLOGY, 2005, 146 (07) :3185-3193