A magnetic particle micro-trap for large trapping surfaces

被引：5
|
作者：
Gooneratne, Chinthaka P. [1 ]
Liang, Cai [1 ]
Giouroudi, Ioanna [2 ]
Kosel, Juergen [1 ]
机构：
[1] King Abdullah Univ Sci & Technol, Div Phys Sci & Engn, Thuwal 23955, Saudi Arabia
[2] Vienna Univ Technol, Inst Sensor & Actuator Syst, A-1040 Vienna, Austria
来源：
EUROSENSORS XXV | 2011年 / 25卷
关键词：
magnetic particle; micro-trap; magnetic force; cytometry;
D O I：
10.1016/j.proeng.2011.12.296
中图分类号：
TH7 [仪器、仪表];
学科分类号：
0804 ; 080401 ; 081102 ;
摘要：
Manipulation of micron-size magnetic particles of the superparamagnetic type contributes significantly in many applications like controlling the antibody/antigen binding process in immunoassays. Specifically, more target biomolecules can be attached/tagged and analyzed since the three dimensional structure of the magnetic particles increases the surface to volume ratio. Additionally, such biomolecular-tagged magnetic particles can be easily manipulated by an external magnetic field due to their superparamagnetic behavior. Therefore, magnetic particle-based immunoassays are extensively applied in micro-flow cytometry. The design of a square-loop micro-trap as a magnetic particle manipulator as well as numerical and experimental analysis is presented. Experimental results showed that the micro-trap could successfully trap and concentrate magnetic particles from a large to a small area with a high spatial range. (C) 2011 Published by Elsevier Ltd.
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页数：4
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