Safety and effectiveness of BNT162b2 mRNA Covid-19 vaccine in adolescents

被引：34

作者：

Choe, Young June ^{[1
]}

Yi, Seonju ^{[2
]}

Hwang, Insob ^{[2
]}

Kim, Jia ^{[2
]}

Park, Young-Joon ^{[2
]}

Cho, Eunhee ^{[2
]}

Jo, Myoungyoun ^{[3
]}

Lee, Hyunju ^{[4
]}

Choi, Eun Hwa ^{[4
]}

机构：

[1] Korea Univ, Anam Hosp, Seoul, South Korea

[2] Korea Dis Control & Prevent Agcy, Cheongju, South Korea

[3] Minist Educ, Sejong, South Korea

[4] Seoul Natl Univ, Coll Med, Seoul, South Korea

来源：

VACCINE | 2022年 / 40卷 / 05期

关键词：

Coronavirus disease 2019; Covid-19; SARS-CoV-2; Vaccine; Vaccination; Adolescent;

D O I：

10.1016/j.vaccine.2021.12.044

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In South Korea, all 12th grade students (highs school seniors) were offered BNT162b2 vaccine starting July 19, 2021; while 10th-11th grade students were not eligible. We conducted a nationwide retrospective cohort study by to determine the safety and effectiveness of BNT162b2 mRNA Covid-19 vaccine in adolescents against SARS-CoV-2 infection. Among 444,313 persons who received the first dose of vaccine, reporting rate for myocarditis and/or pericarditis was 1.8 per 100,000 (95% C.I. 0.8-3.5) among first-dose recipients and 4.3 per 100,000 (95% C.I. 2.6-6.7) in second-dose recipients. Vaccine effectiveness against symptomatic/asymptomatic SARS-CoV-2 infection 14 days post-first dose vaccination was 91.1% (95% C.I. 89.6-92.5), and 14 days post-second dose was 99.1% (95% C.I. 98.5-99.5). In this retrospective cohort study, BNT162b2 vaccination was safe and was associated with a significantly lower risk of SARS-CoV2 infection, suggesting that vaccination in adolescent may reduce the burden of Covid-19. (c) 2021 Elsevier Ltd. All rights reserved.

引用

页码：691 / 694

页数：4

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