Synthesis of some new substituted iodoquinazoline derivatives and their antimicrobial screening

被引：21

作者：

Alafeefy, Ahmed M. ^{[1
]}

El-Azab, Adel S. ^{[2
]}

Mohamed, Menshawy A. ^{[1
]}

Bakhat, Mohamed Afroz ^{[1
]}

Abdel-Hamid, S. G. ^{[1
]}

机构：

[1] AlKharj Univ, Coll Pharm, Dept Pharmaceut Chem, Al Kharj, Saudi Arabia

[2] King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, Riyadh 11451, Saudi Arabia

来源：

JOURNAL OF SAUDI CHEMICAL SOCIETY | 2011年 / 15卷 / 04期

关键词：

Synthesis; 6-Iodo-2-thienylquinazolin-4(3H)-one; Antimicrobial screening; DIHYDROFOLATE-REDUCTASE; PNEUMOCYSTIS-CARINII; RESISTANCE;

D O I：

10.1016/j.jscs.2011.07.005

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new series of 6-iodo-2-thienylquinazolin-4(3H)-one and its fused heterocyclic analogs were prepared and screened for their antimicrobial activity. Compounds 4, 8, 14 and 24 showed remarkable broad spectrum antimicrobial activity. The fused heterocycles, 1,2,4-triazino[3,4-c]quinazoline, benzimidazo[1,2-c]quinazoline and quinazoline-bearing thiazolidinone moiety proved to contribute for antimicrobial activity. The detailed synthesis and their antimicrobial screening are reported. (C) 2011 King Saud University. Production and hosting by Elsevier B.V. All rights reserved.

引用

页码：319 / 325

页数：7

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