Familial Pancreatic Ductal Adenocarcinoma

被引:13
作者
Diaz, Kelly E. [1 ]
Lucas, Aimee L. [1 ,2 ]
机构
[1] Icahn Sch Med Mt Sinai, Dept Med, Samuel Bronfman Dept Med, New York, NY 10029 USA
[2] Icahn Sch Med Mt Sinai, Dept Med, Henry D Janowitz Div Gastroenterol, One Gustave L Levy Pl,Box 1069, New York, NY 10029 USA
关键词
PEUTZ-JEGHERS-SYNDROME; CANCER-RISK; HEREDITARY PANCREATITIS; CONSENSUS GUIDELINES; ALCOHOL-CONSUMPTION; CYSTIC-FIBROSIS; MANAGEMENT; MUTATION; PREVENTION; FUTURE;
D O I
10.1016/j.ajpath.2018.06.026
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Pancreatic ductal adenocarcinoma (PDAC), although a rare disease, has a poor prognosis. With 5-year overall survival of 8%, there is a critical need to detect PDAC early or at a premalignant stage. Current screening methods are largely imaging based, but a more focused screening approach based on modifiable and nonmodifiable risk factors may improve the efficacy and likely outcomes of screening. In addition, the pathologic mechanisms that lead to the development of PDAC are discussed in an effort to further understand the targets of pancreatic cancer screening. The focus of this article will be inherited pancreatic cancer syndromes and familial pancreatic cancer, which together compose up to 10% of PDAC. Understanding the methods and targets of PDAC screening in high-risk individuals may translate to improved morbidity and mortality.
引用
收藏
页码:36 / 43
页数:8
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