The Role of ATG16 in Autophagy and The Ubiquitin Proteasome System

被引：46

作者：

Xiong, Qiuhong ^{[1
]}

Li, Wenjing ^{[1
]}

Li, Ping ^{[1
]}

Yang, Min ^{[1
]}

Wu, Changxin ^{[1
]}

Eichinger, Ludwig ^{[2
]}

机构：

[1] Shanxi Univ, Inst Biomed Sci, 92 Wucheng Rd, Taiyuan 030006, Peoples R China

[2] Univ Cologne, Fac Med, Ctr Biochem, Joseph Stelzmann Str 52, D-50931 Cologne, Germany

来源：

CELLS | 2019年 / 8卷 / 01期

基金：

中国国家自然科学基金;

关键词：

ATG16; autophagy; ubiquitin proteasome system; UPS; crosstalk; GENOME-WIDE ASSOCIATION; PLASMA-MEMBRANE; CROHNS-DISEASE; WD-REPEAT; SELECTIVE AUTOPHAGY; SUSCEPTIBILITY LOCI; CANONICAL AUTOPHAGY; ULK1; COMPLEX; PROTEIN; DEGRADATION;

D O I：

10.3390/cells8010002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Autophagy and the ubiquitin proteasome system (UPS) are the two major cellular degradation pathways, which are critical for the maintenance of cell homeostasis. The two pathways differ in their mechanisms and clients. The evolutionary conserved ATG16 plays a key role in autophagy and appears to link autophagy with the UPS. Here, we review the role of ATG16 in different species. We summarize the current knowledge of its functions in autophagosome membrane expansion and autophagosome formation, in Crohn's disease, and in bacterial sequestration. In addition, we provide information on its autophagy-independent functions and its role in the crosstalk between autophagy and the UPS.

引用

页数：16

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