Asymmetric Synthesis of 3,4-Dihydroquinolin-2-ones via a Stereoselective Palladium-Catalyzed Decarboxylative [4+2]-Cycloaddition

被引：69

作者：

Jin, Jing-Hai ^{[1
,2
]}

Wang, Hao ^{[1
,2
]}

Yang, Zhong-Tao ^{[1
,2
]}

Yang, Wu-Lin ^{[1
,2
]}

Tang, Wenjun ^{[1
,2
,3
]}

Deng, Wei-Ping ^{[1
,2
]}

机构：

[1] East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China

[2] East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, State Key Lab Bioorgan & Nat Prod Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 01期

基金：

中国国家自然科学基金;

关键词：

4+2 CYCLOADDITIONS; CASCADE REACTION; CONSTRUCTION; DERIVATIVES; ACCESS; QUINOLINONES; HETEROCYCLES; ACTIVATION; GENERATION; EFFICIENT;

D O I：

10.1021/acs.orglett.7b03467

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient, palladium-catalyzed, decarboxylative [4 + 2]-cycloaddition of 4-vinyl benzoxazinanones with carboxylic acids has been developed with the employment of P-chiral mono phosphorus ligand BI-DIME, affording a series of structurally diverse 3,4-dihydroquinolin-2-ones bearing two contiguous stereogenic centers in moderate to good yields with good to excellent stereoselectivities.

引用

收藏

页码：104 / 107

页数：4

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